Melikyan GB - Search Results

1

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.

Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Bester SM, et al. Among authors: melikyan gb. Science. 2020 Oct 16;370(6514):360-364. doi: 10.1126/science.abb4808. Science. 2020. PMID: 33060363 Free PMC article.

2

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.

Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Francis AC, et al. Among authors: melikyan gb. PLoS Pathog. 2016 Jun 20;12(6):e1005709. doi: 10.1371/journal.ppat.1005709. eCollection 2016 Jun. PLoS Pathog. 2016. PMID: 27322072 Free PMC article.

3

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Hammonds JE, Beeman N, Ding L, Takushi S, Francis AC, Wang JJ, Melikyan GB, Spearman P. Hammonds JE, et al. Among authors: melikyan gb. PLoS Pathog. 2017 Jan 27;13(1):e1006181. doi: 10.1371/journal.ppat.1006181. eCollection 2017 Jan. PLoS Pathog. 2017. PMID: 28129379 Free PMC article.

4

An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions.

Sood C, Francis AC, Desai TM, Melikyan GB. Sood C, et al. Among authors: melikyan gb. J Biol Chem. 2017 Dec 8;292(49):20196-20207. doi: 10.1074/jbc.M117.818088. Epub 2017 Oct 18. J Biol Chem. 2017. PMID: 29046351 Free PMC article.

5

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport.

Francis AC, Melikyan GB. Francis AC, et al. Among authors: melikyan gb. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. Cell Host Microbe. 2018. PMID: 29649444 Free PMC article.

6

Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

Francis AC, Melikyan GB. Francis AC, et al. Among authors: melikyan gb. Viruses. 2018 May 19;10(5):275. doi: 10.3390/v10050275. Viruses. 2018. PMID: 29783762 Free PMC article. Review.

7

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, Cocklin S. Xu JP, et al. Among authors: melikyan gb. J Drug Des Res. 2018;5(2):1070. Epub 2018 Aug 13. J Drug Des Res. 2018. PMID: 30393786 Free PMC article.

8

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. Koneru PC, et al. Among authors: melikyan gb. Elife. 2019 May 23;8:e46344. doi: 10.7554/eLife.46344. Elife. 2019. PMID: 31120420 Free PMC article.

9

A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.

Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. Siddiqui MA, et al. Among authors: melikyan gb. J Virol. 2019 Jul 30;93(16):e00706-19. doi: 10.1128/JVI.00706-19. Print 2019 Aug 15. J Virol. 2019. PMID: 31167922 Free PMC article.

10

Facile autofluorescence suppression enabling tracking of single viruses in live cells.

Chen YC, Sood C, Francis AC, Melikyan GB, Dickson RM. Chen YC, et al. Among authors: melikyan gb. J Biol Chem. 2019 Dec 13;294(50):19111-19118. doi: 10.1074/jbc.RA119.010268. Epub 2019 Nov 6. J Biol Chem. 2019. PMID: 31694918 Free PMC article.

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