Melhem M - Search Results

1

Receiver Operating Characteristic Analysis and Clinical Trial Simulation to Inform Dose Titration Decisions.

Clements JD, Perez Ruixo JJ, Gibbs JP, Doshi S, Perez Ruixo C, Melhem M. Clements JD, et al. Among authors: melhem m. CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):771-779. doi: 10.1002/psp4.12354. Epub 2018 Oct 15. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30246497 Free PMC article.

2

Population Pharmacokinetics and Pharmacodynamics of the Calcimimetic Etelcalcetide in Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.

Chen P, Olsson Gisleskog P, Perez-Ruixo JJ, Xiao J, Wilkins J, Narayanan A, Gibbs JP, Melhem M. Chen P, et al. Among authors: melhem m. CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):484-94. doi: 10.1002/psp4.12106. Epub 2016 Sep 17. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27639083 Free PMC article.

3

Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis.

Chen P, Melhem M, Xiao J, Kuchimanchi M, Perez Ruixo JJ. Chen P, et al. Among authors: melhem m. J Clin Pharmacol. 2015 Jun;55(6):620-8. doi: 10.1002/jcph.460. Epub 2015 Feb 18. J Clin Pharmacol. 2015. PMID: 25581635 Clinical Trial.

4

Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.

Chen P, Narayanan A, Wu B, Gisleskog PO, Gibbs JP, Chow AT, Melhem M. Chen P, et al. Among authors: melhem m. Clin Pharmacokinet. 2018 Jan;57(1):71-85. doi: 10.1007/s40262-017-0550-4. Clin Pharmacokinet. 2018. PMID: 28508378

5

Pharmacokinetic-pharmacodynamic modelling of neutrophil response to G-CSF in healthy subjects and patients with chemotherapy-induced neutropenia.

Melhem M, Delor I, Pérez-Ruixo JJ, Harrold J, Chow A, Wu L, Jacqmin P. Melhem M, et al. Br J Clin Pharmacol. 2018 May;84(5):911-925. doi: 10.1111/bcp.13504. Epub 2018 Feb 20. Br J Clin Pharmacol. 2018. PMID: 29318653 Free PMC article.

6

Prediction of Survival Benefit of Filgrastim in Adult and Pediatric Patients With Acute Radiation Syndrome.

Harrold J, Gisleskog PO, Perez-Ruixo JJ, Delor I, Chow A, Jacqmin P, Melhem M. Harrold J, et al. Among authors: melhem m. Clin Transl Sci. 2020 Jul;13(4):807-817. doi: 10.1111/cts.12777. Epub 2020 Apr 6. Clin Transl Sci. 2020. PMID: 32112517 Free PMC article.

7

Quantification of Radiation Injury on Neutropenia and the Link between Absolute Neutrophil Count Time Course and Overall Survival in Nonhuman Primates Treated with G-CSF.

Harrold J, Gisleskog PO, Delor I, Jacqmin P, Perez-Ruixo JJ, Narayanan A, Doshi S, Chow A, Yang BB, Melhem M. Harrold J, et al. Among authors: melhem m. Pharm Res. 2020 May 21;37(6):102. doi: 10.1007/s11095-020-02839-3. Pharm Res. 2020. PMID: 32440783 Free PMC article.

8

Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis.

Wu B, Melhem M, Subramanian R, Chen P, Jaramilla Sloey B, Fouqueray B, Hock MB, Skiles GL, Chow AT, Lee E. Wu B, et al. Among authors: melhem m. J Clin Pharmacol. 2018 Jun;58(6):717-726. doi: 10.1002/jcph.1090. Epub 2018 Mar 13. J Clin Pharmacol. 2018. PMID: 29534286 Review.

9

Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis.

Wu L, Melhem M, Subramanian R, Wu B. Wu L, et al. Among authors: melhem m. J Pharmacokinet Pharmacodyn. 2017 Feb;44(1):43-53. doi: 10.1007/s10928-016-9503-z. Epub 2017 Jan 6. J Pharmacokinet Pharmacodyn. 2017. PMID: 28063122

10

Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet.

Chen P, Sohn W, Narayanan A, Gisleskog PO, Melhem M. Chen P, et al. Among authors: melhem m. Br J Clin Pharmacol. 2019 Jun;85(6):1312-1325. doi: 10.1111/bcp.13900. Epub 2019 Apr 25. Br J Clin Pharmacol. 2019. PMID: 30756425 Free PMC article.

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