The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries.
Kutil Z, Skultetyova L, Rauh D, Meleshin M, Snajdr I, Novakova Z, Mikesova J, Pavlicek J, Hadzima M, Baranova P, Havlinova B, Majer P, Schutkowski M, Barinka C.
Kutil Z, et al. Among authors: meleshin m.
FASEB J. 2019 Mar;33(3):4035-4045. doi: 10.1096/fj.201801680R. Epub 2018 Nov 29.
FASEB J. 2019.
PMID: 30496698
Our data thus offer a detailed insight into the substrate preferences of the individual HDAC6 domains at the peptide level, and these findings can in turn help in elucidating the biologic roles of the enzyme and facilitate the development of new domain-specific inhibitors as rese …
Our data thus offer a detailed insight into the substrate preferences of the individual HDAC6 domains at the peptide level, and these findin …