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Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels.
Tricarico D, Mele A, Camerino GM, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Camerino DC. Tricarico D, et al. Among authors: mele a. Mol Pharmacol. 2008 Jul;74(1):50-8. doi: 10.1124/mol.108.046615. Epub 2008 Apr 10. Mol Pharmacol. 2008. PMID: 18403717
The KATP channel is a molecular sensor of atrophy in skeletal muscle.
Tricarico D, Mele A, Camerino GM, Bottinelli R, Brocca L, Frigeri A, Svelto M, George AL Jr, Camerino DC. Tricarico D, et al. Among authors: mele a. J Physiol. 2010 Mar 1;588(Pt 5):773-84. doi: 10.1113/jphysiol.2009.185835. Epub 2010 Jan 11. J Physiol. 2010. PMID: 20064856 Free PMC article.
Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs.
Tricarico D, Rolland JF, Cannone G, Mele A, Cippone V, Laghezza A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Conte Camerino D. Tricarico D, et al. Among authors: mele a. J Pharmacol Exp Ther. 2012 Feb;340(2):266-76. doi: 10.1124/jpet.111.185835. Epub 2011 Oct 25. J Pharmacol Exp Ther. 2012. PMID: 22028392
680 results