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Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery.
Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2308776121. doi: 10.1073/pnas.2308776121. Epub 2024 Jan 22.
Proc Natl Acad Sci U S A. 2024.
PMID: 38252831
Free PMC article.
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics.
Molino D, Pila-Castellanos I, Marjault HB, Dias Amoedo N, Kopp K, Rochin L, Karmi O, Sohn YS, Lines L, Hamaï A, Joly S, Radreau P, Vonderscher J, Codogno P, Giordano F, Machin P, Rossignol R, Meldrum E, Arnoult D, Ruggieri A, Nechushtai R, de Chassey B, Morel E.
Molino D, et al.
EMBO Rep. 2020 Dec 3;21(12):e49019. doi: 10.15252/embr.201949019. Epub 2020 Nov 12.
EMBO Rep. 2020.
PMID: 33180995
Free PMC article.
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Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.
Pila-Castellanos I, Molino D, McKellar J, Lines L, Da Graca J, Tauziet M, Chanteloup L, Mikaelian I, Meyniel-Schicklin L, Codogno P, Vonderscher J, Delevoye C, Moncorgé O, Meldrum E, Goujon C, Morel E, de Chassey B.
Pila-Castellanos I, et al.
PLoS Pathog. 2021 Feb 17;17(2):e1009340. doi: 10.1371/journal.ppat.1009340. eCollection 2021 Feb.
PLoS Pathog. 2021.
PMID: 33596274
Free PMC article.
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An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters.
Marjault HB, Karmi O, Zuo K, Michaeli D, Eisenberg-Domovich Y, Rossetti G, de Chassey B, Vonderscher J, Cabantchik I, Carloni P, Mittler R, Livnah O, Meldrum E, Nechushtai R.
Marjault HB, et al.
Commun Biol. 2022 May 10;5(1):437. doi: 10.1038/s42003-022-03393-x.
Commun Biol. 2022.
PMID: 35538231
Free PMC article.
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Correction: Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.
Pila-Castellanos I, Molino D, McKellar J, Lines L, Da Graca J, Tauziet M, Chanteloup L, Mikaelian I, Meyniel-Schicklin L, Codogno P, Vonderscher J, Delevoye C, Moncorgé O, Meldrum E, Goujon C, Morel E, de Chassey B.
Pila-Castellanos I, et al.
PLoS Pathog. 2021 Mar 31;17(3):e1009485. doi: 10.1371/journal.ppat.1009485. eCollection 2021 Mar.
PLoS Pathog. 2021.
PMID: 33788903
Free PMC article.
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Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.
Jurgeit A, McDowell R, Moese S, Meldrum E, Schwendener R, Greber UF.
Jurgeit A, et al.
PLoS Pathog. 2012;8(10):e1002976. doi: 10.1371/journal.ppat.1002976. Epub 2012 Oct 25.
PLoS Pathog. 2012.
PMID: 23133371
Free PMC article.
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