Melacini G - Search Results

1

Non-Canonical Allostery in Cyclic Nucleotide Dependent Kinases.

Khamina M, Martinez Pomier K, Akimoto M, VanSchouwen B, Melacini G. Khamina M, et al. Among authors: melacini g. J Mol Biol. 2022 Sep 15;434(17):167584. doi: 10.1016/j.jmb.2022.167584. Epub 2022 Apr 12. J Mol Biol. 2022. PMID: 35427632 Review.

2

Definition of an electrostatic relay switch critical for the cAMP-dependent activation of protein kinase A as revealed by the D170A mutant of RIalpha.

Abu-Abed M, Das R, Wang L, Melacini G. Abu-Abed M, et al. Among authors: melacini g. Proteins. 2007 Oct 1;69(1):112-24. doi: 10.1002/prot.21446. Proteins. 2007. PMID: 17596845

3

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G. Mazhab-Jafari MT, et al. Among authors: melacini g. J Am Chem Soc. 2007 Nov 21;129(46):14482-92. doi: 10.1021/ja0753703. Epub 2007 Oct 31. J Am Chem Soc. 2007. PMID: 17973384

4

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G. Das R, et al. Among authors: melacini g. J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29. J Biol Chem. 2009. PMID: 19403523 Free PMC article.

5

Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations.

McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. McNicholl ET, et al. Among authors: melacini g. J Biol Chem. 2010 May 14;285(20):15523-15537. doi: 10.1074/jbc.M110.105783. Epub 2010 Mar 4. J Biol Chem. 2010. PMID: 20202931 Free PMC article.

6

Mapping allostery through the covariance analysis of NMR chemical shifts.

Selvaratnam R, Chowdhury S, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6133-8. doi: 10.1073/pnas.1017311108. Epub 2011 Mar 28. Proc Natl Acad Sci U S A. 2011. PMID: 21444788 Free PMC article.

7

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC).

VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G. VanSchouwen B, et al. Among authors: melacini g. J Biol Chem. 2011 Dec 9;286(49):42655-42669. doi: 10.1074/jbc.M111.277723. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873431 Free PMC article.

8

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.

9

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7. Biophys J. 2012. PMID: 22325287 Free PMC article.

10

Signaling through dynamic linkers as revealed by PKA.

Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Akimoto M, et al. Among authors: melacini g. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6. doi: 10.1073/pnas.1312644110. Epub 2013 Aug 14. Proc Natl Acad Sci U S A. 2013. PMID: 23946424 Free PMC article.

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