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Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells.
Cell Mol Life Sci. 2022 Sep 12;79(10):513. doi: 10.1007/s00018-022-04524-7.
Cell Mol Life Sci. 2022.
PMID: 36097202
Free PMC article.
The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa.
Brandel A, Aigal S, Lagies S, Schlimpert M, Meléndez AV, Xu M, Lehmann A, Hummel D, Fisch D, Madl J, Eierhoff T, Kammerer B, Römer W.
Brandel A, et al. Among authors: melendez av.
Cell Mol Life Sci. 2021 Apr;78(7):3637-3656. doi: 10.1007/s00018-021-03766-1. Epub 2021 Feb 8.
Cell Mol Life Sci. 2021.
PMID: 33555391
Free PMC article.
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Bacterial lectin BambL acts as a B cell superantigen.
Frensch M, Jäger C, Müller PF, Tadić A, Wilhelm I, Wehrum S, Diedrich B, Fischer B, Meléndez AV, Dengjel J, Eibel H, Römer W.
Frensch M, et al. Among authors: melendez av.
Cell Mol Life Sci. 2021 Dec;78(24):8165-8186. doi: 10.1007/s00018-021-04009-z. Epub 2021 Nov 3.
Cell Mol Life Sci. 2021.
PMID: 34731252
Free PMC article.
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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death.
Rosato F, Pasupuleti R, Tomisch J, Meléndez AV, Kolanovic D, Makshakova ON, Wiltschi B, Römer W.
Rosato F, et al. Among authors: melendez av.
J Transl Med. 2022 Dec 9;20(1):578. doi: 10.1186/s12967-022-03794-w.
J Transl Med. 2022.
PMID: 36494671
Free PMC article.
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Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers.
Xu M, Antonova M, Salavei P, Illek K, Meléndez AV, Omidvar R, Thuenauer R, Makshakova O, Römer W.
Xu M, et al. Among authors: melendez av.
Pharmaceutics. 2023 Jan 9;15(1):225. doi: 10.3390/pharmaceutics15010225.
Pharmaceutics. 2023.
PMID: 36678854
Free PMC article.
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A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells.
Tomisch J, Busse V, Rosato F, Makshakova ON, Salavei P, Kittel AS, Gillon E, Lataster L, Imberty A, Meléndez AV, Römer W.
Tomisch J, et al. Among authors: melendez av.
Cells. 2023 Jul 20;12(14):1896. doi: 10.3390/cells12141896.
Cells. 2023.
PMID: 37508560
Free PMC article.
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Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S.
Velasco Cárdenas RM, et al. Among authors: melendez av.
Nat Immunol. 2023 Dec;24(12):2135-2149. doi: 10.1038/s41590-023-01658-z. Epub 2023 Nov 6.
Nat Immunol. 2023.
PMID: 37932456
Free PMC article.
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Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells.
Østevold K, Meléndez AV, Lehmann F, Schmidt G, Aktories K, Schwan C.
Østevold K, et al. Among authors: melendez av.
Oncotarget. 2017 Sep 11;8(44):76686-76698. doi: 10.18632/oncotarget.20805. eCollection 2017 Sep 29.
Oncotarget. 2017.
PMID: 29100341
Free PMC article.
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