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Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer.
Brown BP, Zhang YK, Kim S, Finneran P, Yan Y, Du Z, Kim J, Hartzler AL, LeNoue-Newton ML, Smith AW, Meiler J, Lovly CM. Brown BP, et al. Among authors: meiler j. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2206588119. doi: 10.1073/pnas.2206588119. Epub 2022 Jul 22. Proc Natl Acad Sci U S A. 2022. PMID: 35867821 Free PMC article.
EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib.
Gallant JN, Sheehan JH, Shaver TM, Bailey M, Lipson D, Chandramohan R, Red Brewer M, York SJ, Kris MG, Pietenpol JA, Ladanyi M, Miller VA, Ali SM, Meiler J, Lovly CM. Gallant JN, et al. Among authors: meiler j. Cancer Discov. 2015 Nov;5(11):1155-63. doi: 10.1158/2159-8290.CD-15-0654. Epub 2015 Aug 18. Cancer Discov. 2015. PMID: 26286086 Free PMC article.
EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.
Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E, Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, Vavalà T, Whiteley A, Chen H, Yan Y, Sheehan JH, Meiler J, Morosini D, Ross JS, Stephens PJ, Miller VA, Ali SM, Lovly CM. Konduri K, et al. Among authors: meiler j. Cancer Discov. 2016 Jun;6(6):601-11. doi: 10.1158/2159-8290.CD-16-0075. Epub 2016 Apr 21. Cancer Discov. 2016. PMID: 27102076 Free PMC article.
An Acquired HER2T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.
Hanker AB, Brewer MR, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE Jr, Lalani AS, Cross D, Lovly CM, Meiler J, Arteaga CL. Hanker AB, et al. Among authors: meiler j. Cancer Discov. 2017 Jun;7(6):575-585. doi: 10.1158/2159-8290.CD-16-1431. Epub 2017 Mar 8. Cancer Discov. 2017. PMID: 28274957 Free PMC article.
On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.
Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM. Brown BP, et al. Among authors: meiler j. Clin Cancer Res. 2019 Jun 1;25(11):3341-3351. doi: 10.1158/1078-0432.CCR-18-3829. Epub 2019 Feb 22. Clin Cancer Res. 2019. PMID: 30796031 Free PMC article.
MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.
Logunova NN, Kriukova VV, Shelyakin PV, Egorov ES, Pereverzeva A, Bozhanova NG, Shugay M, Shcherbinin DS, Pogorelyy MV, Merzlyak EM, Zubov VN, Meiler J, Chudakov DM, Apt AS, Britanova OV. Logunova NN, et al. Among authors: meiler j. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13659-13669. doi: 10.1073/pnas.2003170117. Epub 2020 Jun 1. Proc Natl Acad Sci U S A. 2020. PMID: 32482872 Free PMC article.
Lipocalin Blc is a potential heme-binding protein.
Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J. Bozhanova NG, et al. Among authors: meiler j. FEBS Lett. 2021 Jan;595(2):206-219. doi: 10.1002/1873-3468.14001. Epub 2020 Dec 3. FEBS Lett. 2021. PMID: 33210733 Free PMC article.
Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.
Bozhanova NG, Sangha AK, Sevy AM, Gilchuk P, Huang K, Nargi RS, Reidy JX, Trivette A, Carnahan RH, Bukreyev A, Crowe JE Jr, Meiler J. Bozhanova NG, et al. Among authors: meiler j. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31142-31148. doi: 10.1073/pnas.1922654117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229516 Free PMC article.
436 results