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Variation in glucocorticoid sensitivity and the relation with obesity.
Lengton R, Iyer AM, van der Valk ES, Hoogeveen EK, Meijer OC, van der Voorn B, van Rossum EFC. Lengton R, et al. Among authors: meijer oc. Obes Rev. 2022 Mar;23(3):e13401. doi: 10.1111/obr.13401. Epub 2021 Nov 27. Obes Rev. 2022. PMID: 34837448 Free PMC article. Review.
Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation.
van den Heuvel JK, Boon MR, van Hengel I, Peschier-van der Put E, van Beek L, van Harmelen V, van Dijk KW, Pereira AM, Hunt H, Belanoff JK, Rensen PC, Meijer OC. van den Heuvel JK, et al. Among authors: meijer oc. Br J Pharmacol. 2016 Jun;173(11):1793-804. doi: 10.1111/bph.13477. Epub 2016 Apr 24. Br J Pharmacol. 2016. PMID: 26990179 Free PMC article.
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR. Morgan RA, et al. Among authors: meijer oc. Sci Rep. 2017 Sep 6;7(1):10633. doi: 10.1038/s41598-017-10410-1. Sci Rep. 2017. PMID: 28878267 Free PMC article.
Glucocorticoid receptor modulators.
Meijer OC, Koorneef LL, Kroon J. Meijer OC, et al. Ann Endocrinol (Paris). 2018 Jun;79(3):107-111. doi: 10.1016/j.ando.2018.03.004. Epub 2018 May 3. Ann Endocrinol (Paris). 2018. PMID: 29731108 Review.
Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice.
Koorneef LL, van den Heuvel JK, Kroon J, Boon MR, 't Hoen PAC, Hettne KM, van de Velde NM, Kolenbrander KB, Streefland TCM, Mol IM, Sips HCM, Kielbasa SM, Mei H, Belanoff JK, Pereira AM, Oosterveer MH, Hunt H, Rensen PCN, Meijer OC. Koorneef LL, et al. Among authors: meijer oc. Endocrinology. 2018 Dec 1;159(12):3925-3936. doi: 10.1210/en.2018-00671. Endocrinology. 2018. PMID: 30321321
206 results