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Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Bell RMB, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, Coutts A, Sharp MGF, Koerner MV, Allan E, Meijer OC, Houtman R, Odermatt A, Beck KR, Denham SG, Lee P, Homer NZM, Walker BR, Morgan RA. Bell RMB, et al. Among authors: meijer oc. Mol Metab. 2021 Jun;48:101225. doi: 10.1016/j.molmet.2021.101225. Epub 2021 Mar 27. Mol Metab. 2021. PMID: 33785425 Free PMC article.
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff JK, Lucassen PJ, Joëls M, de Kloet ER, Roozendaal B, Hunt H, Meijer OC. Zalachoras I, et al. Among authors: meijer oc. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5. doi: 10.1073/pnas.1219411110. Epub 2013 Apr 23. Proc Natl Acad Sci U S A. 2013. PMID: 23613579 Free PMC article.
Cofactor profiling of the glucocorticoid receptor from a cellular environment.
Desmet SJ, Dejager L, Clarisse D, Thommis J, Melchers D, Bastiaensen N, Ruijtenbeek R, Beck IM, Libert C, Houtman R, Meijer OC, De Bosscher K. Desmet SJ, et al. Among authors: meijer oc. Methods Mol Biol. 2014;1204:83-94. doi: 10.1007/978-1-4939-1346-6_8. Methods Mol Biol. 2014. PMID: 25182763
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR. Morgan RA, et al. Among authors: meijer oc. Sci Rep. 2017 Sep 6;7(1):10633. doi: 10.1038/s41598-017-10410-1. Sci Rep. 2017. PMID: 28878267 Free PMC article.
Androgens modulate glucocorticoid receptor activity in adipose tissue and liver.
Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, Kuipers EN, Backer EA, Kooijman S, Rensen PCN, Homer NZM, Walker BR, Meijer OC, Kroon J. Spaanderman DCE, et al. Among authors: meijer oc. J Endocrinol. 2018 Oct 1:JOE-18-0503.R1. doi: 10.1530/JOE-18-0503. Online ahead of print. J Endocrinol. 2018. PMID: 30400038
205 results