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The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.
Festuccia C, Mancini A, Colapietro A, Gravina GL, Vitale F, Marampon F, Delle Monache S, Pompili S, Cristiano L, Vetuschi A, Tombolini V, Chen Y, Mehrling T. Festuccia C, et al. Among authors: mehrling t. J Hematol Oncol. 2018 Feb 27;11(1):32. doi: 10.1186/s13045-018-0576-6. J Hematol Oncol. 2018. PMID: 29486795 Free PMC article.
Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair.
López-Iglesias AA, Herrero AB, Chesi M, San-Segundo L, González-Méndez L, Hernández-García S, Misiewicz-Krzeminska I, Quwaider D, Martín-Sánchez M, Primo D, Paíno T, Bergsagel PL, Mehrling T, González-Díaz M, San-Miguel JF, Mateos MV, Gutiérrez NC, Garayoa M, Ocio EM. López-Iglesias AA, et al. Among authors: mehrling t. J Hematol Oncol. 2017 Jun 20;10(1):127. doi: 10.1186/s13045-017-0495-y. J Hematol Oncol. 2017. PMID: 28633670 Free PMC article.
Is there hope to treat glioblastoma effectively?
Mehrling T, Gunawardana R. Mehrling T, et al. CNS Oncol. 2015;4(6):377-9. doi: 10.2217/cns.15.33. Epub 2015 Oct 28. CNS Oncol. 2015. PMID: 26507499 Free PMC article.
Correction to: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma.
Festuccia C, Mancini A, Colapietro A, Gravina GL, Vitale F, Marampon F, Delle Monache S, Pompili S, Cristiano L, Vetuschi A, Tombolini V, Chen Y, Mehrling T. Festuccia C, et al. Among authors: mehrling t. J Hematol Oncol. 2018 Mar 14;11(1):38. doi: 10.1186/s13045-018-0587-3. J Hematol Oncol. 2018. PMID: 29540202 Free PMC article.
Establishment and Characterization of a Reliable Xenograft Model of Hodgkin Lymphoma Suitable for the Study of Tumor Origin and the Design of New Therapies.
M'kacher R, Frenzel M, Al Jawhari M, Junker S, Cuceu C, Morat L, Bauchet AL, Stimmer L, Lenain A, Dechamps N, Hempel WM, Pottier G, Heidingsfelder L, Laplagne E, Borie C, Oudrhiri N, Jouni D, Bennaceur-Griscelli A, Colicchio B, Dieterlen A, Girinsky T, Boisgard R, Bourhis J, Bosq J, Mehrling T, Jeandidier E, Carde P. M'kacher R, et al. Among authors: mehrling t. Cancers (Basel). 2018 Oct 31;10(11):414. doi: 10.3390/cancers10110414. Cancers (Basel). 2018. PMID: 30384446 Free PMC article.
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