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Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.
Szőke D, Kovács G, Kemecsei É, Bálint L, Szoták-Ajtay K, Aradi P, Styevkóné Dinnyés A, Mui BL, Tam YK, Madden TD, Karikó K, Kataru RP, Hope MJ, Weissman D, Mehrara BJ, Pardi N, Jakus Z. Szőke D, et al. Among authors: mehrara bj. Nat Commun. 2021 Jun 8;12(1):3460. doi: 10.1038/s41467-021-23546-6. Nat Commun. 2021. PMID: 34103491 Free PMC article.
TGF-beta1 is a negative regulator of lymphatic regeneration during wound repair.
Clavin NW, Avraham T, Fernandez J, Daluvoy SV, Soares MA, Chaudhry A, Mehrara BJ. Clavin NW, et al. Among authors: mehrara bj. Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2113-27. doi: 10.1152/ajpheart.00879.2008. Epub 2008 Oct 10. Am J Physiol Heart Circ Physiol. 2008. PMID: 18849330 Free article.
Fibrosis is a key inhibitor of lymphatic regeneration.
Avraham T, Clavin NW, Daluvoy SV, Fernandez J, Soares MA, Cordeiro AP, Mehrara BJ. Avraham T, et al. Among authors: mehrara bj. Plast Reconstr Surg. 2009 Aug;124(2):438-450. doi: 10.1097/PRS.0b013e3181adcf4b. Plast Reconstr Surg. 2009. PMID: 19644258
Regulation of inflammation and fibrosis by macrophages in lymphedema.
Ghanta S, Cuzzone DA, Torrisi JS, Albano NJ, Joseph WJ, Savetsky IL, Gardenier JC, Chang D, Zampell JC, Mehrara BJ. Ghanta S, et al. Among authors: mehrara bj. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1065-77. doi: 10.1152/ajpheart.00598.2014. Epub 2015 Feb 27. Am J Physiol Heart Circ Physiol. 2015. PMID: 25724493 Free PMC article.
Th2 cytokines inhibit lymphangiogenesis.
Savetsky IL, Ghanta S, Gardenier JC, Torrisi JS, García Nores GD, Hespe GE, Nitti MD, Kataru RP, Mehrara BJ. Savetsky IL, et al. Among authors: mehrara bj. PLoS One. 2015 Jun 3;10(6):e0126908. doi: 10.1371/journal.pone.0126908. eCollection 2015. PLoS One. 2015. PMID: 26039103 Free PMC article.
380 results