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Page 1
Structural genomics of pathogenic protozoa: an overview.
Fan E, Baker D, Fields S, Gelb MH, Buckner FS, Van Voorhis WC, Phizicky E, Dumont M, Mehlin C, Grayhack E, Sullivan M, Verlinde C, Detitta G, Meldrum DR, Merritt EA, Earnest T, Soltis M, Zucker F, Myler PJ, Schoenfeld L, Kim D, Worthey L, Lacount D, Vignali M, Li J, Mondal S, Massey A, Carroll B, Gulde S, Luft J, Desoto L, Holl M, Caruthers J, Bosch J, Robien M, Arakaki T, Holmes M, Le Trong I, Hol WG. Fan E, et al. Among authors: mehlin c. Methods Mol Biol. 2008;426:497-513. doi: 10.1007/978-1-60327-058-8_33. Methods Mol Biol. 2008. PMID: 18542886 Review.
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.
Caruthers J, Zucker F, Worthey E, Myler PJ, Buckner F, Van Voorhuis W, Mehlin C, Boni E, Feist T, Luft J, Gulde S, Lauricella A, Kaluzhniy O, Anderson L, Le Trong I, Holmes MA, Earnest T, Soltis M, Hodgson KO, Hol WG, Merritt EA. Caruthers J, et al. Among authors: mehlin c. Protein Sci. 2005 Nov;14(11):2887-94. doi: 10.1110/ps.051783005. Epub 2005 Sep 30. Protein Sci. 2005. PMID: 16199669 Free PMC article.
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Robien MA, et al. Among authors: mehlin c. Proteins. 2006 Mar 15;62(3):570-7. doi: 10.1002/prot.20801. Proteins. 2006. PMID: 16345073
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Hol WG, Merritt EA. Holmes MA, et al. Among authors: mehlin c. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Mar 1;62(Pt 3):180-5. doi: 10.1107/S1744309106005847. Epub 2006 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16511296 Free PMC article.
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.
Mehlin C, Boni E, Buckner FS, Engel L, Feist T, Gelb MH, Haji L, Kim D, Liu C, Mueller N, Myler PJ, Reddy JT, Sampson JN, Subramanian E, Van Voorhis WC, Worthey E, Zucker F, Hol WG. Mehlin C, et al. Mol Biochem Parasitol. 2006 Aug;148(2):144-60. doi: 10.1016/j.molbiopara.2006.03.011. Epub 2006 Apr 18. Mol Biochem Parasitol. 2006. PMID: 16644028
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Bosch J, et al. Among authors: mehlin c. J Med Chem. 2006 Oct 5;49(20):5939-46. doi: 10.1021/jm060429m. J Med Chem. 2006. PMID: 17004709
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.
Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG. Caruthers J, et al. Among authors: mehlin c. Proteins. 2006 Feb 1;62(2):338-42. doi: 10.1002/prot.20764. Proteins. 2006. PMID: 16304640
Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, Merritt EA. Holmes MA, et al. Among authors: mehlin c. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt 5):427-31. doi: 10.1107/S1744309106010876. Epub 2006 Apr 12. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16682767 Free PMC article.
Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine.
Schnick C, Robien MA, Brzozowski AM, Dodson EJ, Murshudov GN, Anderson L, Luft JR, Mehlin C, Hol WG, Brannigan JA, Wilkinson AJ. Schnick C, et al. Among authors: mehlin c. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1245-54. doi: 10.1107/S0907444905020251. Epub 2005 Aug 16. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16131758
27 results