Megson IL - Search Results

1

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.

Rushworth GF, Megson IL. Rushworth GF, et al. Among authors: megson il. Pharmacol Ther. 2014 Feb;141(2):150-9. doi: 10.1016/j.pharmthera.2013.09.006. Epub 2013 Sep 28. Pharmacol Ther. 2014. PMID: 24080471 Review.

2

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy: A Failure of Academic Clinical Science.

Sandilands EA, Rees JMB, Raja K, Dhaun N, Morrison EE, Hickson K, Wraight J, Gray T, Briody L, Cameron S, Thompson AP, Johnston NR, Uren N, Goddard J, Treweeke A, Rushworth G, Webb DJ, Bateman DN, Norrie J, Megson IL, Eddleston M. Sandilands EA, et al. Among authors: megson il. Clin Pharmacol Ther. 2022 Jun;111(6):1222-1238. doi: 10.1002/cpt.2541. Epub 2022 Feb 23. Clin Pharmacol Ther. 2022. PMID: 35098531 Free PMC article. Clinical Trial.

3

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

Treweeke AT, Winterburn TJ, Mackenzie I, Barrett F, Barr C, Rushworth GF, Dransfield I, MacRury SM, Megson IL. Treweeke AT, et al. Among authors: megson il. Diabetologia. 2012 Nov;55(11):2920-8. doi: 10.1007/s00125-012-2685-z. Epub 2012 Aug 31. Diabetologia. 2012. PMID: 22935960 Free PMC article. Clinical Trial.

4

12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition.

Maskrey BH, Rushworth GF, Law MH, Treweeke AT, Wei J, Leslie SJ, Megson IL, Whitfield PD. Maskrey BH, et al. Among authors: megson il. J Inflamm (Lond). 2014 Oct 23;11(1):33. doi: 10.1186/s12950-014-0033-4. eCollection 2014. J Inflamm (Lond). 2014. PMID: 25349537 Free PMC article.

5

Evaluation of the antioxidant properties of N-acetylcysteine in human platelets: prerequisite for bioconversion to glutathione for antioxidant and antiplatelet activity.

Gibson KR, Neilson IL, Barrett F, Winterburn TJ, Sharma S, MacRury SM, Megson IL. Gibson KR, et al. Among authors: megson il. J Cardiovasc Pharmacol. 2009 Oct;54(4):319-26. doi: 10.1097/FJC.0b013e3181b6e77b. J Cardiovasc Pharmacol. 2009. PMID: 19668088

6

Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes.

Gibson KR, Winterburn TJ, Barrett F, Sharma S, MacRury SM, Megson IL. Gibson KR, et al. Among authors: megson il. Cardiovasc Diabetol. 2011 May 21;10:43. doi: 10.1186/1475-2840-10-43. Cardiovasc Diabetol. 2011. PMID: 21600014 Free PMC article.

7

Bioactive polyphenols and cardiovascular disease: chemical antagonists, pharmacological agents or xenobiotics that drive an adaptive response?

Goszcz K, Duthie GG, Stewart D, Leslie SJ, Megson IL. Goszcz K, et al. Among authors: megson il. Br J Pharmacol. 2017 Jun;174(11):1209-1225. doi: 10.1111/bph.13708. Epub 2017 Feb 2. Br J Pharmacol. 2017. PMID: 28071785 Free PMC article. Review.

8

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells.

Goszcz K, Deakin SJ, Duthie GG, Stewart D, Megson IL. Goszcz K, et al. Among authors: megson il. Oxid Med Cell Longev. 2017;2017:9260701. doi: 10.1155/2017/9260701. Epub 2017 Sep 7. Oxid Med Cell Longev. 2017. PMID: 29081896 Free PMC article.

9

2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors.

Keown OP, Winterburn TJ, Wainwright CL, Macrury SM, Neilson I, Barrett F, Leslie SJ, Megson IL. Keown OP, et al. Among authors: megson il. Br J Clin Pharmacol. 2010 Aug;70(2):180-8. doi: 10.1111/j.1365-2125.2010.03697.x. Br J Clin Pharmacol. 2010. PMID: 20653671 Free PMC article.

10

NO and sGC-stimulating NO donors.

Megson IL, Miller MR. Megson IL, et al. Handb Exp Pharmacol. 2009;(191):247-76. doi: 10.1007/978-3-540-68964-5_12. Handb Exp Pharmacol. 2009. PMID: 19089333 Review.

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