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Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3.
Jimenez L, Silva A, Calissi G, Grenho I, Monteiro R, Mayoral-Varo V, Blanco-Aparicio C, Pastor J, Bustos V, Bracher F, Megías D, Ferreira BI, Link W. Jimenez L, et al. Among authors: megias d. J Gerontol A Biol Sci Med Sci. 2022 Aug 12;77(8):1485-1493. doi: 10.1093/gerona/glab265. J Gerontol A Biol Sci Med Sci. 2022. PMID: 34508571 Free PMC article.
Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage.
García-Beccaria M, Martínez P, Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C, Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA. García-Beccaria M, et al. Among authors: megias d. EMBO Mol Med. 2015 Jul;7(7):930-49. doi: 10.15252/emmm.201404497. EMBO Mol Med. 2015. PMID: 25971796 Free PMC article.
Lysosomal trapping of palbociclib and its functional implications.
Llanos S, Megias D, Blanco-Aparicio C, Hernández-Encinas E, Rovira M, Pietrocola F, Serrano M. Llanos S, et al. Among authors: megias d. Oncogene. 2019 May;38(20):3886-3902. doi: 10.1038/s41388-019-0695-8. Epub 2019 Jan 28. Oncogene. 2019. PMID: 30692638 Free PMC article.
Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance.
Machado S, Silva A, De Sousa-Coelho AL, Duarte I, Grenho I, Santos B, Mayoral-Varo V, Megias D, Sánchez-Cabo F, Dopazo A, Ferreira BI, Link W. Machado S, et al. Among authors: megias d. Cancers (Basel). 2020 Dec 9;12(12):3689. doi: 10.3390/cancers12123689. Cancers (Basel). 2020. PMID: 33316942 Free PMC article.
mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity.
Jimenez L, Amenabar C, Mayoral-Varo V, Mackenzie TA, Ramos MC, Silva A, Calissi G, Grenho I, Blanco-Aparicio C, Pastor J, Megías D, Ferreira BI, Link W. Jimenez L, et al. Among authors: megias d. Molecules. 2022 Aug 24;27(17):5414. doi: 10.3390/molecules27175414. Molecules. 2022. PMID: 36080182 Free PMC article.
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.
Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. Priego N, et al. Among authors: megias d. Nat Med. 2018 Jul;24(7):1024-1035. doi: 10.1038/s41591-018-0044-4. Epub 2018 Jun 11. Nat Med. 2018. PMID: 29892069 Free article.
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