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Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach.
Qin C, Chu Y, Feng W, Fromont C, He S, Ali J, Lee JB, Zgair A, Berton M, Bettonte S, Liu R, Yang L, Monmaturapoj T, Medrano-Padial C, Ugalde AAR, Vetrugno D, Ee SY, Sheriston C, Wu Y, Stocks MJ, Fischer PM, Gershkovich P. Qin C, et al. Among authors: medrano padial c. J Control Release. 2021 Jan 10;329:1077-1089. doi: 10.1016/j.jconrel.2020.10.036. Epub 2020 Oct 20. J Control Release. 2021. PMID: 33091528
Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.
Chu Y, Qin C, Feng W, Sheriston C, Jane Khor Y, Medrano-Padial C, Watson BE, Chan T, Ling B, Stocks MJ, Fischer PM, Gershkovich P. Chu Y, et al. Among authors: medrano padial c. Int J Pharm. 2021 Jun 1;602:120621. doi: 10.1016/j.ijpharm.2021.120621. Epub 2021 Apr 21. Int J Pharm. 2021. PMID: 33892057
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