Medina DL - Search Results

1

Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis.

Bellomo F, De Leo E, Taranta A, Giaquinto L, Di Giovamberardino G, Montefusco S, Rega LR, Pastore A, Medina DL, Di Bernardo D, De Matteis MA, Emma F. Bellomo F, et al. Among authors: medina dl. Int J Mol Sci. 2021 Nov 27;22(23):12829. doi: 10.3390/ijms222312829. Int J Mol Sci. 2021. PMID: 34884638 Free PMC article.

2

The phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activation.

Moskot M, Montefusco S, Jakóbkiewicz-Banecka J, Mozolewski P, Węgrzyn A, Di Bernardo D, Węgrzyn G, Medina DL, Ballabio A, Gabig-Cimińska M. Moskot M, et al. Among authors: medina dl. J Biol Chem. 2014 Jun 13;289(24):17054-69. doi: 10.1074/jbc.M114.555300. Epub 2014 Apr 25. J Biol Chem. 2014. PMID: 24770416 Free PMC article.

3

A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data.

Gambardella G, Peluso I, Montefusco S, Bansal M, Medina DL, Lawrence N, di Bernardo D. Gambardella G, et al. Among authors: medina dl. BMC Bioinformatics. 2015 Sep 3;16:279. doi: 10.1186/s12859-015-0700-3. BMC Bioinformatics. 2015. PMID: 26334955 Free PMC article.

4

FGF signalling regulates bone growth through autophagy.

Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C. Cinque L, et al. Among authors: medina dl. Nature. 2015 Dec 10;528(7581):272-5. doi: 10.1038/nature16063. Epub 2015 Nov 23. Nature. 2015. PMID: 26595272

5

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells.

Rega LR, Polishchuk E, Montefusco S, Napolitano G, Tozzi G, Zhang J, Bellomo F, Taranta A, Pastore A, Polishchuk R, Piemonte F, Medina DL, Catz SD, Ballabio A, Emma F. Rega LR, et al. Among authors: medina dl. Kidney Int. 2016 Apr;89(4):862-73. doi: 10.1016/j.kint.2015.12.045. Kidney Int. 2016. PMID: 26994576 Free article.

6

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL.

De Leo MG, Staiano L, Vicinanza M, Luciani A, Carissimo A, Mutarelli M, Di Campli A, Polishchuk E, Di Tullio G, Morra V, Levtchenko E, Oltrabella F, Starborg T, Santoro M, Di Bernardo D, Devuyst O, Lowe M, Medina DL, Ballabio A, De Matteis MA. De Leo MG, et al. Among authors: medina dl. Nat Cell Biol. 2016 Aug;18(8):839-850. doi: 10.1038/ncb3386. Epub 2016 Jul 11. Nat Cell Biol. 2016. PMID: 27398910 Free PMC article.

7

High-content drug screening for rare diseases.

Bellomo F, Medina DL, De Leo E, Panarella A, Emma F. Bellomo F, et al. Among authors: medina dl. J Inherit Metab Dis. 2017 Jul;40(4):601-607. doi: 10.1007/s10545-017-0055-1. Epub 2017 Jun 7. J Inherit Metab Dis. 2017. PMID: 28593466 Review.

8

Comparing structural and transcriptional drug networks reveals signatures of drug activity and toxicity in transcriptional responses.

Sirci F, Napolitano F, Pisonero-Vaquero S, Carrella D, Medina DL, di Bernardo D. Sirci F, et al. Among authors: medina dl. NPJ Syst Biol Appl. 2017 Aug 25;3:23. doi: 10.1038/s41540-017-0022-3. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28861278 Free PMC article.

9

gene2drug: a computational tool for pathway-based rational drug repositioning.

Napolitano F, Carrella D, Mandriani B, Pisonero-Vaquero S, Sirci F, Medina DL, Brunetti-Pierri N, di Bernardo D. Napolitano F, et al. Among authors: medina dl. Bioinformatics. 2018 May 1;34(9):1498-1505. doi: 10.1093/bioinformatics/btx800. Bioinformatics. 2018. PMID: 29236977

10

High-Throughput Screening Identifies Kinase Inhibitors That Increase Dual Adeno-Associated Viral Vector Transduction In Vitro and in Mouse Retina.

Maddalena A, Dell'Aquila F, Giovannelli P, Tiberi P, Wanderlingh LG, Montefusco S, Tornabene P, Iodice C, Visconte F, Carissimo A, Medina DL, Castoria G, Auricchio A. Maddalena A, et al. Among authors: medina dl. Hum Gene Ther. 2018 Aug;29(8):886-901. doi: 10.1089/hum.2017.220. Epub 2018 Jul 5. Hum Gene Ther. 2018. PMID: 29641320 Free PMC article.

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