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Targeting PI3K/AKT/mTOR network for treatment of leukemia.
Bertacchini J, Heidari N, Mediani L, Capitani S, Shahjahani M, Ahmadzadeh A, Saki N. Bertacchini J, et al. Among authors: mediani l. Cell Mol Life Sci. 2015 Jun;72(12):2337-47. doi: 10.1007/s00018-015-1867-5. Epub 2015 Feb 25. Cell Mol Life Sci. 2015. PMID: 25712020 Review.
Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.
Bertacchini J, Guida M, Accordi B, Mediani L, Martelli AM, Barozzi P, Petricoin E 3rd, Liotta L, Milani G, Giordan M, Luppi M, Forghieri F, De Pol A, Cocco L, Basso G, Marmiroli S. Bertacchini J, et al. Among authors: mediani l. Leukemia. 2014 Nov;28(11):2197-205. doi: 10.1038/leu.2014.123. Epub 2014 Apr 4. Leukemia. 2014. PMID: 24699302
Inhibition of Ras-mediated signaling pathways in CML stem cells.
Bertacchini J, Ketabchi N, Mediani L, Capitani S, Marmiroli S, Saki N. Bertacchini J, et al. Among authors: mediani l. Cell Oncol (Dordr). 2015 Dec;38(6):407-18. doi: 10.1007/s13402-015-0248-2. Epub 2015 Oct 12. Cell Oncol (Dordr). 2015. PMID: 26458816 Review.
Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.
Mediani L, Gibellini F, Bertacchini J, Frasson C, Bosco R, Accordi B, Basso G, Bonora M, Calabrò ML, Mattiolo A, Sgarbi G, Baracca A, Pinton P, Riva G, Rampazzo E, Petrizza L, Prodi L, Milani D, Luppi M, Potenza L, De Pol A, Cocco L, Capitani S, Marmiroli S. Mediani L, et al. Oncotarget. 2016 Feb 2;7(5):5521-37. doi: 10.18632/oncotarget.6315. Oncotarget. 2016. PMID: 26575168 Free PMC article.
Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S. Morelli FF, et al. Among authors: mediani l. Cell Rep. 2017 Aug 29;20(9):2100-2115. doi: 10.1016/j.celrep.2017.08.018. Cell Rep. 2017. PMID: 28854361 Free PMC article.
Clusterin enhances AKT2-mediated motility of normal and cancer prostate cells through a PTEN and PHLPP1 circuit.
Bertacchini J, Mediani L, Beretti F, Guida M, Ghalali A, Brugnoli F, Bertagnolo V, Petricoin E, Poti F, Arioli J, Anselmi L, Bari A, McCubrey J, Martelli AM, Cocco L, Capitani S, Marmiroli S. Bertacchini J, et al. Among authors: mediani l. J Cell Physiol. 2019 Jul;234(7):11188-11199. doi: 10.1002/jcp.27768. Epub 2018 Nov 22. J Cell Physiol. 2019. PMID: 30565691 Free article.
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