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A widely distributed gene cluster compensates for uricase loss in hominids.
Liu Y, Jarman JB, Low YS, Augustijn HE, Huang S, Chen H, DeFeo ME, Sekiba K, Hou BH, Meng X, Weakley AM, Cabrera AV, Zhou Z, van Wezel G, Medema MH, Ganesan C, Pao AC, Gombar S, Dodd D. Liu Y, et al. Among authors: medema mh. Cell. 2023 Aug 3;186(16):3400-3413.e20. doi: 10.1016/j.cell.2023.06.010. Cell. 2023. PMID: 37541197
Metabolome-guided genome mining of RiPP natural products.
Zdouc MM, van der Hooft JJJ, Medema MH. Zdouc MM, et al. Among authors: medema mh. Trends Pharmacol Sci. 2023 Aug;44(8):532-541. doi: 10.1016/j.tips.2023.06.004. Epub 2023 Jun 29. Trends Pharmacol Sci. 2023. PMID: 37391295 Review.
Genome mining of metabolic gene clusters in the Rubiaceae family.
Correia de Lemos SM, Paschoal AR, Guyot R, Medema M, Domingues DS. Correia de Lemos SM, et al. Comput Struct Biotechnol J. 2023 Nov 20;23:22-33. doi: 10.1016/j.csbj.2023.11.034. eCollection 2024 Dec. Comput Struct Biotechnol J. 2023. PMID: 38075396 Free PMC article.
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.
Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: medema mh. ACS Chem Biol. 2024 Apr 11. doi: 10.1021/acschembio.4c00034. Online ahead of print. ACS Chem Biol. 2024. PMID: 38602492
147 results