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Towards the sustainable discovery and development of new antibiotics.
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Miethke M, et al. Among authors: medema mh. Nat Rev Chem. 2021 Oct;5(10):726-749. doi: 10.1038/s41570-021-00313-1. Epub 2021 Aug 19. Nat Rev Chem. 2021. PMID: 37118182 Review.
The tomato cytochrome P450 CYP712G1 catalyses the double oxidation of orobanchol en route to the rhizosphere signalling strigolactone, solanacol.
Wang Y, Durairaj J, Suárez Duran HG, van Velzen R, Flokova K, Liao CY, Chojnacka A, MacFarlane S, Schranz ME, Medema MH, van Dijk ADJ, Dong L, Bouwmeester HJ. Wang Y, et al. Among authors: medema mh. New Phytol. 2022 Sep;235(5):1884-1899. doi: 10.1111/nph.18272. Epub 2022 Jun 18. New Phytol. 2022. PMID: 35612785 Free PMC article.
MS/MS networking guided analysis of molecule and gene cluster families.
Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC. Nguyen DD, et al. Among authors: medema mh. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2611-20. doi: 10.1073/pnas.1303471110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798442 Free PMC article.
Standardization for natural product synthetic biology.
Zhao H, Medema MH. Zhao H, et al. Among authors: medema mh. Nat Prod Rep. 2016 Aug 27;33(8):920-4. doi: 10.1039/c6np00030d. Epub 2016 Jun 17. Nat Prod Rep. 2016. PMID: 27313083 Free PMC article. Review.
148 results