Mead AN - Search Results

1

The predictive validity of the rat self-administration model for abuse liability.

O'Connor EC, Chapman K, Butler P, Mead AN. O'Connor EC, et al. Among authors: mead an. Neurosci Biobehav Rev. 2011 Jan;35(3):912-38. doi: 10.1016/j.neubiorev.2010.10.012. Epub 2010 Oct 29. Neurosci Biobehav Rev. 2011. PMID: 21036191 Free article. Review.

2

Tramadol acts as a weak reinforcer in the rat self-administration model, consistent with its low abuse liability in humans.

O'Connor EC, Mead AN. O'Connor EC, et al. Among authors: mead an. Pharmacol Biochem Behav. 2010 Sep;96(3):279-86. doi: 10.1016/j.pbb.2010.05.018. Epub 2010 May 24. Pharmacol Biochem Behav. 2010. PMID: 20580909

3

The alpha4beta2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats.

O'Connor EC, Parker D, Rollema H, Mead AN. O'Connor EC, et al. Among authors: mead an. Psychopharmacology (Berl). 2010 Feb;208(3):365-76. doi: 10.1007/s00213-009-1739-5. Epub 2009 Dec 5. Psychopharmacology (Berl). 2010. PMID: 19967529

4

Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials.

Mead AN, Amouzadeh HR, Chapman K, Ewart L, Giarola A, Jackson SJ, Jarvis P, Jordaan P, Redfern W, Traebert M, Valentin JP, Vargas HM. Mead AN, et al. Regul Toxicol Pharmacol. 2016 Oct;80:348-57. doi: 10.1016/j.yrtph.2016.05.002. Epub 2016 May 4. Regul Toxicol Pharmacol. 2016. PMID: 27155597 Free article.

5

The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice.

O'Connor EC, Crombag HS, Mead AN, Stephens DN. O'Connor EC, et al. Among authors: mead an. Neuropsychopharmacology. 2010 Jul;35(8):1807-17. doi: 10.1038/npp.2010.48. Epub 2010 Apr 7. Neuropsychopharmacology. 2010. PMID: 20375996 Free PMC article.

6

A translational pharmacology approach to understanding the predictive value of abuse potential assessments.

Horton DB, Potter DM, Mead AN. Horton DB, et al. Among authors: mead an. Behav Pharmacol. 2013 Sep;24(5-6):410-36. doi: 10.1097/FBP.0b013e3283644d2e. Behav Pharmacol. 2013. PMID: 23873088 Review.

7

Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints.

Jenkinson S, Goody SMG, Bassyouni A, Jones R, Otto-Bruc A, Duquennoy S, DaSilva JK, Butler P, Mead A. Jenkinson S, et al. J Pharmacol Toxicol Methods. 2020 Jul-Aug;104:106899. doi: 10.1016/j.vascn.2020.106899. Epub 2020 Jul 21. J Pharmacol Toxicol Methods. 2020. PMID: 32702414

8

Assessing the Value of the Zebrafish Conditioned Place Preference Model for Predicting Human Abuse Potential.

Brock AJ, Goody SMG, Mead AN, Sudwarts A, Parker MO, Brennan CH. Brock AJ, et al. Among authors: mead an. J Pharmacol Exp Ther. 2017 Oct;363(1):66-79. doi: 10.1124/jpet.117.242628. Epub 2017 Aug 8. J Pharmacol Exp Ther. 2017. PMID: 28790193 Free PMC article.

9

Appropriate experimental approaches for predicting abuse potential and addictive qualities in preclinical drug discovery.

Mead AN. Mead AN. Expert Opin Drug Discov. 2014 Nov;9(11):1281-91. doi: 10.1517/17460441.2014.956077. Epub 2014 Sep 1. Expert Opin Drug Discov. 2014. PMID: 25176123 Review.

10

The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.

Ewart L, Aylott M, Deurinck M, Engwall M, Gallacher DJ, Geys H, Jarvis P, Ju H, Leishman D, Leong L, McMahon N, Mead A, Milliken P, Suter W, Teisman A, Van Ammel K, Vargas HM, Wallis R, Valentin JP. Ewart L, et al. Toxicol Sci. 2014 Dec;142(2):427-35. doi: 10.1093/toxsci/kfu198. Epub 2014 Sep 21. Toxicol Sci. 2014. PMID: 25246669

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