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N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Hoveyda HR, Fraser GL, Zoute L, Dutheuil G, Schils D, Brantis C, Lapin A, Parcq J, Guitard S, Lenoir F, Bousmaqui ME, Rorive S, Hospied S, Blanc S, Bernard J, Ooms F, McNelis JC, Olefsky JM. Hoveyda HR, et al. Among authors: mcnelis jc. Bioorg Med Chem. 2018 Oct 1;26(18):5169-5180. doi: 10.1016/j.bmc.2018.09.015. Epub 2018 Sep 18. Bioorg Med Chem. 2018. PMID: 30253886
Macrophages, immunity, and metabolic disease.
McNelis JC, Olefsky JM. McNelis JC, et al. Immunity. 2014 Jul 17;41(1):36-48. doi: 10.1016/j.immuni.2014.05.010. Immunity. 2014. PMID: 25035952 Free article. Review.
GPR43 Potentiates β-Cell Function in Obesity.
McNelis JC, Lee YS, Mayoral R, van der Kant R, Johnson AM, Wollam J, Olefsky JM. McNelis JC, et al. Diabetes. 2015 Sep;64(9):3203-17. doi: 10.2337/db14-1938. Epub 2015 May 28. Diabetes. 2015. PMID: 26023106 Free PMC article.
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice.
Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM. Oh DY, et al. Nat Med. 2014 Aug;20(8):942-7. doi: 10.1038/nm.3614. Epub 2014 Jul 6. Nat Med. 2014. PMID: 24997608 Free PMC article.
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.
Osborn O, Oh DY, McNelis J, Sanchez-Alavez M, Talukdar S, Lu M, Li P, Thiede L, Morinaga H, Kim JJ, Heinrichsdorff J, Nalbandian S, Ofrecio JM, Scadeng M, Schenk S, Hadcock J, Bartfai T, Olefsky JM. Osborn O, et al. J Clin Invest. 2012 Jul;122(7):2444-53. doi: 10.1172/JCI61953. Epub 2012 Jun 1. J Clin Invest. 2012. PMID: 22653059 Free PMC article.
11 results