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Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022.
Caldwell N, Afshar R, Baragaña B, Bustinduy AL, Caffrey CR, Collins JJ, Fusco D, Garba A, Gardner M, Gomes M, Hoffmann KF, Hsieh M, Lo NC, McNamara CW, Nono JK, Padalino G, Read KD, Roestenberg M, Spangenberg T, Specht S, Gilbert IH. Caldwell N, et al. Among authors: mcnamara cw. ACS Infect Dis. 2023 May 12;9(5):1046-1055. doi: 10.1021/acsinfecdis.3c00081. Epub 2023 Apr 21. ACS Infect Dis. 2023. PMID: 37083395 Free PMC article. Review.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH. Baragaña B, et al. Among authors: mcnamara cw. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20. Proc Natl Acad Sci U S A. 2019. PMID: 30894487 Free PMC article.
MalDA, Accelerating Malaria Drug Discovery.
Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, McNamara CW, Gamo FJ, Burrows J, Fidock DA, Goldberg DE, Gilbert IH, Wirth DF, Winzeler EA; Malaria Drug Accelerator Consortium. Yang T, et al. Among authors: mcnamara cw. Trends Parasitol. 2021 Jun;37(6):493-507. doi: 10.1016/j.pt.2021.01.009. Epub 2021 Feb 26. Trends Parasitol. 2021. PMID: 33648890 Free PMC article. Review.
Prioritization of Molecular Targets for Antimalarial Drug Discovery.
Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, Wirth D, Wyllie S, Fidock DA, Baragaña B, Winzeler EA, Gilbert IH. Forte B, et al. Among authors: mcnamara cw. ACS Infect Dis. 2021 Oct 8;7(10):2764-2776. doi: 10.1021/acsinfecdis.1c00322. Epub 2021 Sep 15. ACS Infect Dis. 2021. PMID: 34523908 Free PMC article.
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
Swann J, Corey V, Scherer CA, Kato N, Comer E, Maetani M, Antonova-Koch Y, Reimer C, Gagaring K, Ibanez M, Plouffe D, Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, Campo B, Winzeler EA, Meister S. Swann J, et al. Among authors: mcnamara cw. ACS Infect Dis. 2016 Apr 8;2(4):281-293. doi: 10.1021/acsinfecdis.5b00143. Epub 2016 Feb 10. ACS Infect Dis. 2016. PMID: 27275010 Free PMC article.
Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.
Abraham M, Gagaring K, Martino ML, Vanaerschot M, Plouffe DM, Calla J, Godinez-Macias KP, Du AY, Wree M, Antonova-Koch Y, Eribez K, Luth MR, Ottilie S, Fidock DA, McNamara CW, Winzeler EA. Abraham M, et al. Among authors: mcnamara cw. ACS Infect Dis. 2020 Apr 10;6(4):613-628. doi: 10.1021/acsinfecdis.9b00482. Epub 2020 Mar 4. ACS Infect Dis. 2020. PMID: 32078764 Free PMC article.
Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads.
Hulverson MA, Choi R, McCloskey MC, Whitman GR, Ojo KK, Michaels SA, Somepalli M, Love MS, McNamara CW, Rabago LM, Barrett LK, Verlinde CLMJ, Arnold SLM, Striepen B, Jimenez-Alfaro D, Ballell L, Fernández E, Greenwood MN, Las Heras L, Calderón F, Van Voorhis WC. Hulverson MA, et al. Among authors: mcnamara cw. ACS Infect Dis. 2021 May 14;7(5):1275-1282. doi: 10.1021/acsinfecdis.1c00076. Epub 2021 Mar 19. ACS Infect Dis. 2021. PMID: 33740373
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.
Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA. Nam TG, et al. Among authors: mcnamara cw. ACS Chem Biol. 2011 Nov 18;6(11):1214-22. doi: 10.1021/cb200105d. Epub 2011 Sep 8. ACS Chem Biol. 2011. PMID: 21866942 Free PMC article.
68 results