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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.
Buesen R, Chorley BN, da Silva Lima B, Daston G, Deferme L, Ebbels T, Gant TW, Goetz A, Greally J, Gribaldo L, Hackermüller J, Hubesch B, Jennen D, Johnson K, Kanno J, Kauffmann HM, Laffont M, McMullen P, Meehan R, Pemberton M, Perdichizzi S, Piersma AH, Sauer UG, Schmidt K, Seitz H, Sumida K, Tollefsen KE, Tong W, Tralau T, van Ravenzwaay B, Weber RJM, Worth A, Yauk C, Poole A. Buesen R, et al. Among authors: mcmullen p. Regul Toxicol Pharmacol. 2017 Dec;91 Suppl 1(Suppl 1):S3-S13. doi: 10.1016/j.yrtph.2017.09.002. Epub 2017 Sep 25. Regul Toxicol Pharmacol. 2017. PMID: 28958911 Free PMC article. Review.
Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays.
McMullen PD, Andersen ME, Cholewa B, Clewell HJ 3rd, Dunnick KM, Hartman JK, Mansouri K, Minto MS, Nicolas CI, Phillips MB, Slattery S, Yoon M, Clewell RA. McMullen PD, et al. Toxicol In Vitro. 2018 Apr;48:310-317. doi: 10.1016/j.tiv.2018.01.027. Epub 2018 Jan 31. Toxicol In Vitro. 2018. PMID: 29391263 Free article. Review.
A toxicogenomic approach for the risk assessment of the food contaminant acetamide.
Nault R, Bals B, Teymouri F, Black MB, Andersen ME, McMullen PD, Krishnan S, Kuravadi N, Paul N, Kumar S, Kannan K, Jayachandra KC, Alagappan L, Patel BD, Bogen KT, Gollapudi BB, Klaunig JE, Zacharewski TR, Bringi V. Nault R, et al. Toxicol Appl Pharmacol. 2020 Feb 1;388:114872. doi: 10.1016/j.taap.2019.114872. Epub 2019 Dec 24. Toxicol Appl Pharmacol. 2020. PMID: 31881176 Free PMC article.
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME. Bhattacharya S, et al. Among authors: mcmullen p. Front Physiol. 2012 Dec 14;3:462. doi: 10.3389/fphys.2012.00462. eCollection 2012. Front Physiol. 2012. PMID: 23248599 Free PMC article.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. Godoy P, et al. Among authors: mcmullen p. Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Arch Toxicol. 2013. PMID: 23974980 Free PMC article. Review.
151 results