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Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.
Vendeville S, Tahri A, Hu L, Demin S, Cooymans L, Vos A, Kwanten L, Van den Berg J, Battles MB, McLellan JS, Koul A, Raboisson P, Roymans D, Jonckers THM. Vendeville S, et al. Among authors: mclellan js. J Med Chem. 2020 Aug 13;63(15):8046-8058. doi: 10.1021/acs.jmedchem.0c00226. Epub 2020 Jun 15. J Med Chem. 2020. PMID: 32407115
Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Battles MB, Langedijk JP, Furmanova-Hollenstein P, Chaiwatpongsakorn S, Costello HM, Kwanten L, Vranckx L, Vink P, Jaensch S, Jonckers TH, Koul A, Arnoult E, Peeples ME, Roymans D, McLellan JS. Battles MB, et al. Among authors: mclellan js. Nat Chem Biol. 2016 Feb;12(2):87-93. doi: 10.1038/nchembio.1982. Epub 2015 Dec 7. Nat Chem Biol. 2016. PMID: 26641933 Free PMC article.
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
Roymans D, Alnajjar SS, Battles MB, Sitthicharoenchai P, Furmanova-Hollenstein P, Rigaux P, Berg JVD, Kwanten L, Ginderen MV, Verheyen N, Vranckx L, Jaensch S, Arnoult E, Voorzaat R, Gallup JM, Larios-Mora A, Crabbe M, Huntjens D, Raboisson P, Langedijk JP, Ackermann MR, McLellan JS, Vendeville S, Koul A. Roymans D, et al. Among authors: mclellan js. Nat Commun. 2017 Aug 1;8(1):167. doi: 10.1038/s41467-017-00170-x. Nat Commun. 2017. PMID: 28761099 Free PMC article.
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS. Jones HG, et al. Among authors: mclellan js. PLoS Pathog. 2018 Mar 6;14(3):e1006935. doi: 10.1371/journal.ppat.1006935. eCollection 2018 Mar. PLoS Pathog. 2018. PMID: 29509814 Free PMC article.
Iterative screen optimization maximizes the efficiency of macromolecular crystallization.
Jones HG, Wrapp D, Gilman MSA, Battles MB, Wang N, Sacerdote S, Chuang GY, Kwong PD, McLellan JS. Jones HG, et al. Among authors: mclellan js. Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):123-131. doi: 10.1107/S2053230X18017338. Epub 2019 Jan 24. Acta Crystallogr F Struct Biol Commun. 2019. PMID: 30713164 Free PMC article.
Respiratory syncytial virus entry and how to block it.
Battles MB, McLellan JS. Battles MB, et al. Among authors: mclellan js. Nat Rev Microbiol. 2019 Apr;17(4):233-245. doi: 10.1038/s41579-019-0149-x. Nat Rev Microbiol. 2019. PMID: 30723301 Free PMC article. Review.
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