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A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies.
Barber C, Antonucci V, Baumann JC, Brown R, Covey-Crump E, Elder D, Elliott E, Fennell JW, Gallou F, Ide ND, Jordine G, Kallemeyn JM, Lauwers D, Looker AR, Lovelle LE, McLaughlin M, Molzahn R, Ott M, Schils D, Oestrich RS, Stevenson N, Talavera P, Teasdale A, Urquhart MW, Varie DL, Welch D. Barber C, et al. Among authors: mclaughlin m. Regul Toxicol Pharmacol. 2017 Nov;90:22-28. doi: 10.1016/j.yrtph.2017.08.008. Epub 2017 Aug 16. Regul Toxicol Pharmacol. 2017. PMID: 28822875
Design of an in vitro biocatalytic cascade for the manufacture of islatravir.
Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H. Huffman MA, et al. Among authors: mclaughlin m. Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484. Science. 2019. PMID: 31806816
Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose.
Nawrat CC, Whittaker AM, Huffman MA, McLaughlin M, Cohen RD, Andreani T, Ding B, Li H, Weisel M, Tschaen DM. Nawrat CC, et al. Among authors: mclaughlin m. Org Lett. 2020 Mar 20;22(6):2167-2172. doi: 10.1021/acs.orglett.0c00239. Epub 2020 Feb 28. Org Lett. 2020. PMID: 32108487
Process Chemistry in Antiviral Research.
Zhong YL, Yasuda N, Li H, McLaughlin M, Tschaen D. Zhong YL, et al. Among authors: mclaughlin m. Top Curr Chem (Cham). 2016 Dec;374(6):77. doi: 10.1007/s41061-016-0076-5. Epub 2016 Nov 2. Top Curr Chem (Cham). 2016. PMID: 27807768 Review.
Synthesis of a naphthyridone p38 MAP kinase inhibitor.
Chung JY, Cvetovich RJ, McLaughlin M, Amato J, Tsay FR, Jensen M, Weissman S, Zewge D. Chung JY, et al. Among authors: mclaughlin m. J Org Chem. 2006 Oct 27;71(22):8602-9. doi: 10.1021/jo061618f. J Org Chem. 2006. PMID: 17064039
Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone.
Patel NR, Nawrat CC, McLaughlin M, Xu Y, Huffman MA, Yang H, Li H, Whittaker AM, Andreani T, Lévesque F, Fryszkowska A, Brunskill A, Tschaen DM, Maloney KM. Patel NR, et al. Among authors: mclaughlin m. Org Lett. 2020 Jun 19;22(12):4659-4664. doi: 10.1021/acs.orglett.0c01431. Epub 2020 Jun 9. Org Lett. 2020. PMID: 32516536
1,513 results