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R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm.
Shide K, Kameda T, Markovtsov V, Shimoda HK, Tonkin E, Fang S, Liu C, Gelman M, Lang W, Romero J, McLaughlin J, Bhamidipati S, Clough J, Low C, Reitsma A, Siu S, Pine P, Park G, Torneros A, Duan M, Singh R, Payan DG, Matsunaga T, Hitoshi Y, Shimoda K. Shide K, et al. Among authors: mclaughlin j. Blood. 2011 Jun 23;117(25):6866-75. doi: 10.1182/blood-2010-01-262535. Epub 2011 Apr 29. Blood. 2011. PMID: 21531978 Free article.
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Baltgalvis KA, White K, Li W, Claypool MD, Lang W, Alcantara R, Singh BK, Friera AM, McLaughlin J, Hansen D, McCaughey K, Nguyen H, Smith IJ, Godinez G, Shaw SJ, Goff D, Singh R, Markovtsov V, Sun TQ, Jenkins Y, Uy G, Li Y, Pan A, Gururaja T, Lau D, Park G, Hitoshi Y, Payan DG, Kinsella TM. Baltgalvis KA, et al. Among authors: mclaughlin j. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1128-45. doi: 10.1152/ajpheart.00839.2013. Epub 2014 Feb 21. Am J Physiol Heart Circ Physiol. 2014. PMID: 24561866 Free PMC article.
Multiple roles for the receptor tyrosine kinase axl in tumor formation.
Holland SJ, Powell MJ, Franci C, Chan EW, Friera AM, Atchison RE, McLaughlin J, Swift SE, Pali ES, Yam G, Wong S, Lasaga J, Shen MR, Yu S, Xu W, Hitoshi Y, Bogenberger J, Nör JE, Payan DG, Lorens JB. Holland SJ, et al. Among authors: mclaughlin j. Cancer Res. 2005 Oct 15;65(20):9294-303. doi: 10.1158/0008-5472.CAN-05-0993. Cancer Res. 2005. PMID: 16230391
R-253 disrupts microtubule networks in multiple tumor cell lines.
Gururaja TL, Goff D, Kinoshita T, Goldstein E, Yung S, McLaughlin J, Pali E, Huang J, Singh R, Daniel-Issakani S, Hitoshi Y, Cooper RD, Payan DG. Gururaja TL, et al. Among authors: mclaughlin j. Clin Cancer Res. 2006 Jun 15;12(12):3831-42. doi: 10.1158/1078-0432.CCR-06-0168. Clin Cancer Res. 2006. PMID: 16778111
Cellular localization and antiproliferative effect of peptides discovered from a functional screen of a retrovirally delivered random peptide library.
Hitoshi Y, Gururaja T, Pearsall DM, Lang W, Sharma P, Huang B, Catalano SM, McLaughlin J, Pali E, Peelle B, Vialard J, Janicot M, Wouters W, Luyten W, Bennett MK, Anderson DC, Payan DG, Lorens JB, Bogenberger J, Demo S. Hitoshi Y, et al. Among authors: mclaughlin j. Chem Biol. 2003 Oct;10(10):975-87. doi: 10.1016/j.chembiol.2003.09.009. Chem Biol. 2003. PMID: 14583264 No abstract available.
2,775 results