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NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. Tu S, et al. Among authors: mckercher sr. Nat Commun. 2017 Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8. Nat Commun. 2017. PMID: 29133852 Free PMC article.
Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.
Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA. Li H, et al. Among authors: mckercher sr. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9397-402. doi: 10.1073/pnas.0802876105. Epub 2008 Jul 1. Proc Natl Acad Sci U S A. 2008. PMID: 18599437 Free PMC article.
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.
Nagar S, Noveral SM, Trudler D, Lopez KM, McKercher SR, Han X, Yates JR 3rd, Piña-Crespo JC, Nakanishi N, Satoh T, Okamoto SI, Lipton SA. Nagar S, et al. Among authors: mckercher sr. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4048-E4056. doi: 10.1073/pnas.1613067114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461502 Free PMC article.
78 results