McKenna R - Search Results

1

Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors.

Mboge MY, Kota A, McKenna R, Frost SC. Mboge MY, et al. Among authors: mckenna r. Int J Med Chem. 2018 Jul 16;2018:2906519. doi: 10.1155/2018/2906519. eCollection 2018. Int J Med Chem. 2018. PMID: 30112206 Free PMC article. Review.

2

Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.

Clemente JC, Robbins A, Graña P, Paleo MR, Correa JF, Villaverde MC, Sardina FJ, Govindasamy L, Agbandje-McKenna M, McKenna R, Dunn BM, Sussman F. Clemente JC, et al. Among authors: mckenna r. J Med Chem. 2008 Feb 28;51(4):852-60. doi: 10.1021/jm701170f. Epub 2008 Jan 24. J Med Chem. 2008. PMID: 18215016

3

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.

Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R. Wagner J, et al. Among authors: mckenna r. Bioorg Med Chem. 2010 Jul 15;18(14):4873-8. doi: 10.1016/j.bmc.2010.06.028. Epub 2010 Jun 15. Bioorg Med Chem. 2010. PMID: 20598552 Free PMC article.

4

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.

Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT. Biswas S, et al. Among authors: mckenna r. Bioorg Med Chem. 2011 Jun 15;19(12):3732-8. doi: 10.1016/j.bmc.2011.05.006. Epub 2011 May 10. Bioorg Med Chem. 2011. PMID: 21620713

5

Role of zinc in catalytic activity of carbonic anhydrase IX.

Tu C, Foster L, Alvarado A, McKenna R, Silverman DN, Frost SC. Tu C, et al. Among authors: mckenna r. Arch Biochem Biophys. 2012 May;521(1-2):90-4. doi: 10.1016/j.abb.2012.03.017. Epub 2012 Mar 23. Arch Biochem Biophys. 2012. PMID: 22465027 Free PMC article.

6

Insights towards sulfonamide drug specificity in α-carbonic anhydrases.

Aggarwal M, Kondeti B, McKenna R. Aggarwal M, et al. Among authors: mckenna r. Bioorg Med Chem. 2013 Mar 15;21(6):1526-33. doi: 10.1016/j.bmc.2012.08.019. Epub 2012 Aug 28. Bioorg Med Chem. 2013. PMID: 22985956 Free PMC article.

7

Structural annotation of human carbonic anhydrases.

Aggarwal M, Boone CD, Kondeti B, McKenna R. Aggarwal M, et al. Among authors: mckenna r. J Enzyme Inhib Med Chem. 2013 Apr;28(2):267-77. doi: 10.3109/14756366.2012.737323. Epub 2012 Nov 9. J Enzyme Inhib Med Chem. 2013. PMID: 23137351 Review.

8

Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.

Biswas S, Carta F, Scozzafava A, McKenna R, Supuran CT. Biswas S, et al. Among authors: mckenna r. Bioorg Med Chem. 2013 Apr 15;21(8):2314-2318. doi: 10.1016/j.bmc.2013.02.022. Epub 2013 Feb 21. Bioorg Med Chem. 2013. PMID: 23490152

9

Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.

Biswas S, McKenna R, Supuran CT. Biswas S, et al. Among authors: mckenna r. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5646-9. doi: 10.1016/j.bmcl.2013.08.019. Epub 2013 Aug 13. Bioorg Med Chem Lett. 2013. PMID: 23993330

10

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.

Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R. Pinard MA, et al. Among authors: mckenna r. Bioorg Med Chem. 2013 Nov 15;21(22):7210-5. doi: 10.1016/j.bmc.2013.08.033. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24090602

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