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Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring JT, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, Supuran CT. Nocentini A, et al. Among authors: mckenna r. J Med Chem. 2018 Jun 28;61(12):5380-5394. doi: 10.1021/acs.jmedchem.8b00625. Epub 2018 Jun 13. J Med Chem. 2018. PMID: 29851481
Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.
Duda DM, Yoshioka C, Govindasamy L, An H, Tu C, Silverman DN, McKenna R. Duda DM, et al. Among authors: mckenna r. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):849-52. doi: 10.1107/s0907444902003700. Epub 2002 Apr 26. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11976500
X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R. Fisher SZ, et al. Among authors: mckenna r. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt 7):618-22. doi: 10.1107/S1744309106020446. Epub 2006 Jun 10. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16820676 Free PMC article.
940 results