McKenna R - Search Results

1

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site.

Singh S, Lomelino CL, Mboge MY, Frost SC, McKenna R. Singh S, et al. Among authors: mckenna r. Molecules. 2018 Apr 30;23(5):1045. doi: 10.3390/molecules23051045. Molecules. 2018. PMID: 29710858 Free PMC article. Review.

2

Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.

Duda DM, Yoshioka C, Govindasamy L, An H, Tu C, Silverman DN, McKenna R. Duda DM, et al. Among authors: mckenna r. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):849-52. doi: 10.1107/s0907444902003700. Epub 2002 Apr 26. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11976500

3

Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.

Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R. Fisher Z, et al. Among authors: mckenna r. Biochemistry. 2005 Feb 1;44(4):1097-105. doi: 10.1021/bi0480279. Biochemistry. 2005. PMID: 15667203

4

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.

Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R. Fisher SZ, et al. Among authors: mckenna r. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt 7):618-22. doi: 10.1107/S1744309106020446. Epub 2006 Jun 10. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16820676 Free PMC article.

5

Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1).

Fisher SZ, Tariku I, Case NM, Tu C, Seron T, Silverman DN, Linser PJ, McKenna R. Fisher SZ, et al. Among authors: mckenna r. Biochim Biophys Acta. 2006 Aug;1764(8):1413-9. doi: 10.1016/j.bbapap.2006.06.013. Epub 2006 Jul 20. Biochim Biophys Acta. 2006. PMID: 16920039

6

Location of binding sites in small molecule rescue of human carbonic anhydrase II.

Bhatt D, Fisher SZ, Tu C, McKenna R, Silverman DN. Bhatt D, et al. Among authors: mckenna r. Biophys J. 2007 Jan 15;92(2):562-70. doi: 10.1529/biophysj.106.093203. Epub 2006 Oct 27. Biophys J. 2007. PMID: 17071654 Free PMC article.

7

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.

Fisher SZ, Maupin CM, Budayova-Spano M, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Voth GA, McKenna R. Fisher SZ, et al. Among authors: mckenna r. Biochemistry. 2007 Mar 20;46(11):2930-7. doi: 10.1021/bi062066y. Epub 2007 Feb 24. Biochemistry. 2007. PMID: 17319692 Free article.

8

Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.

Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN. Fisher SZ, et al. Among authors: mckenna r. Biochemistry. 2007 Mar 27;46(12):3803-13. doi: 10.1021/bi602620k. Epub 2007 Mar 2. Biochemistry. 2007. PMID: 17330962

9

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.

Elder I, Fisher Z, Laipis PJ, Tu C, McKenna R, Silverman DN. Elder I, et al. Among authors: mckenna r. Proteins. 2007 Jul 1;68(1):337-43. doi: 10.1002/prot.21403. Proteins. 2007. PMID: 17427958

10

Entrapment of carbon dioxide in the active site of carbonic anhydrase II.

Domsic JF, Avvaru BS, Kim CU, Gruner SM, Agbandje-McKenna M, Silverman DN, McKenna R. Domsic JF, et al. Among authors: mckenna r. J Biol Chem. 2008 Nov 7;283(45):30766-71. doi: 10.1074/jbc.M805353200. Epub 2008 Sep 2. J Biol Chem. 2008. PMID: 18768466 Free PMC article.

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