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The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core.
Jenkins T, Northall SJ, Ptchelkine D, Lever R, Cubbon A, Betts H, Taresco V, Cooper CDO, McHugh PJ, Soultanas P, Bolt EL. Jenkins T, et al. Among authors: mchugh pj. NAR Cancer. 2021 Jan 12;3(1):zcaa043. doi: 10.1093/narcan/zcaa043. eCollection 2021 Mar. NAR Cancer. 2021. PMID: 34316696 Free PMC article.
The SNM1A DNA repair nuclease.
Baddock HT, Yosaatmadja Y, Newman JA, Schofield CJ, Gileadi O, McHugh PJ. Baddock HT, et al. Among authors: mchugh pj. DNA Repair (Amst). 2020 Nov;95:102941. doi: 10.1016/j.dnarep.2020.102941. Epub 2020 Jul 31. DNA Repair (Amst). 2020. PMID: 32866775 Free PMC article. Review.
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID. Nguyen GH, et al. Among authors: mchugh pj. Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016. Chem Biol. 2013. PMID: 23352139 Free PMC article.
XPF-ERCC1: Linchpin of DNA crosslink repair.
McHugh PJ. McHugh PJ. PLoS Genet. 2020 Apr 9;16(4):e1008616. doi: 10.1371/journal.pgen.1008616. eCollection 2020 Apr. PLoS Genet. 2020. PMID: 32271747 Free PMC article. No abstract available.
103 results