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HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.
Biondini M, Kiepas A, El-Houjeiri L, Annis MG, Hsu BE, Fortier AM, Morin G, Martina JA, Sirois I, Aguilar-Mahecha A, Gruosso T, McGuirk S, Rose AAN, Tokat UM, Johnson RM, Sahin O, Bareke E, St-Pierre J, Park M, Basik M, Majewski J, Puertollano R, Pause A, Huang S, Keler T, Siegel PM. Biondini M, et al. Among authors: mcguirk s. Oncogene. 2022 Mar;41(12):1701-1717. doi: 10.1038/s41388-022-02206-z. Epub 2022 Feb 2. Oncogene. 2022. PMID: 35110681
PGC-1α supports glutamine metabolism in breast cancer.
McGuirk S, Gravel SP, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. McGuirk S, et al. Cancer Metab. 2013 Dec 5;1(1):22. doi: 10.1186/2049-3002-1-22. Cancer Metab. 2013. PMID: 24304688 Free PMC article.
Metabolic Fitness and Plasticity in Cancer Progression.
McGuirk S, Audet-Delage Y, St-Pierre J. McGuirk S, et al. Trends Cancer. 2020 Jan;6(1):49-61. doi: 10.1016/j.trecan.2019.11.009. Epub 2020 Jan 3. Trends Cancer. 2020. PMID: 31952781 Review.
Estrogen-related receptors are targetable ROS sensors.
Vernier M, Dufour CR, McGuirk S, Scholtes C, Li X, Bourmeau G, Kuasne H, Park M, St-Pierre J, Audet-Walsh E, Giguère V. Vernier M, et al. Among authors: mcguirk s. Genes Dev. 2020 Apr 1;34(7-8):544-559. doi: 10.1101/gad.330746.119. Epub 2020 Feb 20. Genes Dev. 2020. PMID: 32079653 Free PMC article.
145 results