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Page 1
Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10+16 mutation.
Dando O, McGeachan R, McQueen J, Baxter P, Rockley N, McAlister H, Prasad A, He X, King D, Rose J, Jones PB, Tulloch J, Chandran S, Smith C, Hardingham G, Spires-Jones TL. Dando O, et al. Among authors: mcgeachan r. medRxiv [Preprint]. 2024 Apr 12:2024.04.09.24305501. doi: 10.1101/2024.04.09.24305501. medRxiv. 2024. PMID: 38645146 Free PMC article. Preprint.
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, Jackson RJ, Catterson JH, Spires-Jones MP, Rose J, Waybright L, Caggiano AO, King D, Gobbo F, Davies C, Hooley M, Dunnett S, Tempelaar R, Meftah S, Tzioras M, Hamby ME, Izzo NJ, Catalano SM, Durrant CS, Smith C, Dando O, Spires-Jones TL. Colom-Cadena M, et al. Among authors: mcgeachan r. Acta Neuropathol. 2024 Feb 6;147(1):32. doi: 10.1007/s00401-023-02679-6. Acta Neuropathol. 2024. PMID: 38319380 Free PMC article.
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
Taylor LW, Simzer EM, Pimblett C, Lacey-Solymar OTT, McGeachan RI, Meftah S, Rose JL, Spires-Jones MP, Holt K, Catterson JH, Koch H, Liaquat I, Clarke JH, Skidmore J, Smith C, Booker SA, Brennan PM, Spires-Jones TL, Durrant CS. Taylor LW, et al. Among authors: mcgeachan ri. Acta Neuropathol. 2024 Jan 4;147(1):7. doi: 10.1007/s00401-023-02667-w. Acta Neuropathol. 2024. PMID: 38175261 Free PMC article.
Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.
Colom-Cadena M, Davies C, Sirisi S, Lee JE, Simzer EM, Tzioras M, Querol-Vilaseca M, Sánchez-Aced É, Chang YY, Holt K, McGeachan RI, Rose J, Tulloch J, Wilkins L, Smith C, Andrian T, Belbin O, Pujals S, Horrocks MH, Lleó A, Spires-Jones TL. Colom-Cadena M, et al. Among authors: mcgeachan ri. Neuron. 2023 Jul 19;111(14):2170-2183.e6. doi: 10.1016/j.neuron.2023.04.020. Epub 2023 May 15. Neuron. 2023. PMID: 37192625 Free article.
Predictive blood biomarkers and brain changes associated with age-related cognitive decline.
Saunders TS, Pozzolo FE, Heslegrave A, King D, McGeachan RI, Spires-Jones MP, Harris SE, Ritchie C, Muniz-Terrera G, Deary IJ, Cox SR, Zetterberg H, Spires-Jones TL. Saunders TS, et al. Among authors: mcgeachan ri. Brain Commun. 2023 Apr 6;5(3):fcad113. doi: 10.1093/braincomms/fcad113. eCollection 2023. Brain Commun. 2023. PMID: 37180996 Free PMC article.
Synaptic degeneration in Alzheimer disease.
Tzioras M, McGeachan RI, Durrant CS, Spires-Jones TL. Tzioras M, et al. Among authors: mcgeachan ri. Nat Rev Neurol. 2023 Jan;19(1):19-38. doi: 10.1038/s41582-022-00749-z. Epub 2022 Dec 13. Nat Rev Neurol. 2023. PMID: 36513730 Review.
Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.
Gadd DA, Hillary RF, McCartney DL, Shi L, Stolicyn A, Robertson NA, Walker RM, McGeachan RI, Campbell A, Xueyi S, Barbu MC, Green C, Morris SW, Harris MA, Backhouse EV, Wardlaw JM, Steele JD, Oyarzún DA, Muniz-Terrera G, Ritchie C, Nevado-Holgado A, Chandra T, Hayward C, Evans KL, Porteous DJ, Cox SR, Whalley HC, McIntosh AM, Marioni RE. Gadd DA, et al. Among authors: mcgeachan ri. Nat Commun. 2022 Aug 9;13(1):4670. doi: 10.1038/s41467-022-32319-8. Nat Commun. 2022. PMID: 35945220 Free PMC article.
Characterizing the molecular and immune landscape of canine bladder cancer.
Cronise KE, Das S, Hernandez BG, Regan DP, Dailey DD, McGeachan RI, Lana SE, Page RL, Gustafson DL, Duval DL. Cronise KE, et al. Among authors: mcgeachan ri. Vet Comp Oncol. 2022 Mar;20(1):69-81. doi: 10.1111/vco.12740. Epub 2021 Jun 1. Vet Comp Oncol. 2022. PMID: 34021685 Free PMC article.