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PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
Nikolatou K, Sandilands E, Román-Fernández A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM. Nikolatou K, et al. Among authors: mcgarry l. EMBO J. 2023 Sep 18;42(18):e113987. doi: 10.15252/embj.2023113987. Epub 2023 Aug 14. EMBO J. 2023. PMID: 37577760 Free PMC article.
The phospholipid PI(3,4)P2 is an apical identity determinant.
Román-Fernández Á, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM. Román-Fernández Á, et al. Among authors: mcgarry l. Nat Commun. 2018 Nov 28;9(1):5041. doi: 10.1038/s41467-018-07464-8. Nat Commun. 2018. PMID: 30487552 Free PMC article.
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Nacke M, Sandilands E, Nikolatou K, Román-Fernández Á, Mason S, Patel R, Lilla S, Yelland T, Galbraith LCA, Freckmann EC, McGarry L, Morton JP, Shanks E, Leung HY, Markert E, Ismail S, Zanivan S, Blyth K, Bryant DM. Nacke M, et al. Among authors: mcgarry l. Nat Commun. 2021 Mar 12;12(1):1623. doi: 10.1038/s41467-021-21847-4. Nat Commun. 2021. PMID: 33712589 Free PMC article.
Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma.
Spiliopoulou P, Spear S, Mirza H, Garner I, McGarry L, Grundland-Freile F, Cheng Z, Ennis DP, Iyer N, McNamara S, Natoli M, Mason S, Blyth K, Adams PD, Roxburgh P, Fuchter MJ, Brown B, McNeish IA. Spiliopoulou P, et al. Among authors: mcgarry l. Mol Cancer Ther. 2022 Apr 1;21(4):522-534. doi: 10.1158/1535-7163.MCT-21-0743. Mol Cancer Ther. 2022. PMID: 35131874 Free PMC article.
Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.
Freckmann EC, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan TRM, Hedley A, Strachan D, Salji M, Morton JP, McGarry L, Leung HY, Sansom OJ, Miller CJ, Bryant DM. Freckmann EC, et al. Among authors: mcgarry l. Nat Commun. 2022 Sep 9;13(1):5317. doi: 10.1038/s41467-022-32958-x. Nat Commun. 2022. PMID: 36085324 Free PMC article.
Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.
Román-Fernández A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM. Román-Fernández A, et al. Among authors: mcgarry l. Sci Adv. 2023 Feb 3;9(5):eabq1858. doi: 10.1126/sciadv.abq1858. Epub 2023 Feb 3. Sci Adv. 2023. PMID: 36735782 Free PMC article.
The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels.
Sandilands E, Freckmann EC, Cumming EM, Román-Fernández A, McGarry L, Anand J, Galbraith L, Mason S, Patel R, Nixon C, Cartwright J, Leung HY, Blyth K, Bryant DM. Sandilands E, et al. Among authors: mcgarry l. J Cell Biol. 2023 Apr 3;222(4):e202206115. doi: 10.1083/jcb.202206115. Epub 2023 Feb 28. J Cell Biol. 2023. PMID: 36880595 Free PMC article.
120 results