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A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates.
Sabnis S, Kumarasinghe ES, Salerno T, Mihai C, Ketova T, Senn JJ, Lynn A, Bulychev A, McFadyen I, Chan J, Almarsson Ö, Stanton MG, Benenato KE. Sabnis S, et al. Among authors: mcfadyen i. Mol Ther. 2018 Jun 6;26(6):1509-1519. doi: 10.1016/j.ymthe.2018.03.010. Epub 2018 Mar 14. Mol Ther. 2018. PMID: 29653760 Free PMC article.
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines.
Hassett KJ, Benenato KE, Jacquinet E, Lee A, Woods A, Yuzhakov O, Himansu S, Deterling J, Geilich BM, Ketova T, Mihai C, Lynn A, McFadyen I, Moore MJ, Senn JJ, Stanton MG, Almarsson Ö, Ciaramella G, Brito LA. Hassett KJ, et al. Among authors: mcfadyen i. Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. doi: 10.1016/j.omtn.2019.01.013. Epub 2019 Feb 7. Mol Ther Nucleic Acids. 2019. PMID: 30785039 Free PMC article.
mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Mauger DM, et al. Among authors: mcfadyen ij. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. doi: 10.1073/pnas.1908052116. Epub 2019 Nov 11. Proc Natl Acad Sci U S A. 2019. PMID: 31712433 Free PMC article.
Therapeutic enzyme engineering using a generative neural network.
Giessel A, Dousis A, Ravichandran K, Smith K, Sur S, McFadyen I, Zheng W, Licht S. Giessel A, et al. Among authors: mcfadyen i. Sci Rep. 2022 Jan 27;12(1):1536. doi: 10.1038/s41598-022-05195-x. Sci Rep. 2022. PMID: 35087131 Free PMC article.
Consensus on managing open ankle fractures in the frail patient.
Guryel E, McEwan J, Qureshi AA, Robertson A, Ahluwalia R; Open Ankle Fracture of the Frail (OAFF) Collaborative Group; OAFF Collaborative Group; Baxter M, Mason L, Eardley W, McFadyen I, Trompeter A, Giblin AV, Handley B, Lahoti O. Guryel E, et al. Among authors: mcfadyen i. Bone Jt Open. 2024 Mar 22;5(3):236-242. doi: 10.1302/2633-1462.53.BJO-2023-0155.R1. Bone Jt Open. 2024. PMID: 38516934 Free PMC article.
119 results