McElroy S - Search Results

1

Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors.

Gatta V, Ilina P, Porter A, McElroy S, Tammela P. Gatta V, et al. Among authors: mcelroy s. Int J Mol Sci. 2019 Jun 25;20(12):3112. doi: 10.3390/ijms20123112. Int J Mol Sci. 2019. PMID: 31242708 Free PMC article.

2

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.

Parnell E, Koschinski A, Zaccolo M, Cameron RT, Baillie GS, Baillie GL, Porter A, McElroy SP, Yarwood SJ. Parnell E, et al. Among authors: mcelroy sp. Biochim Biophys Acta. 2015 Jul;1853(7):1749-58. doi: 10.1016/j.bbamcr.2015.04.009. Epub 2015 Apr 23. Biochim Biophys Acta. 2015. PMID: 25913012 Free PMC article.

3

The importance of triaging in determining the quality of output from high-throughput screening.

Jones P, McElroy S, Morrison A, Pannifer A. Jones P, et al. Among authors: mcelroy s. Future Med Chem. 2015;7(14):1847-52. doi: 10.4155/fmc.15.121. Epub 2015 Sep 30. Future Med Chem. 2015. PMID: 26419190 Free article. No abstract available.

4

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.

Parnell E, McElroy SP, Wiejak J, Baillie GL, Porter A, Adams DR, Rehmann H, Smith BO, Yarwood SJ. Parnell E, et al. Sci Rep. 2017 Mar 22;7(1):294. doi: 10.1038/s41598-017-00455-7. Sci Rep. 2017. PMID: 28331191 Free PMC article.

5

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs).

Heap RE, Hope AG, Pearson LA, Reyskens KMSE, McElroy SP, Hastie CJ, Porter DW, Arthur JSC, Gray DW, Trost M. Heap RE, et al. Among authors: mcelroy sp. SLAS Discov. 2017 Dec;22(10):1193-1202. doi: 10.1177/2472555217717473. Epub 2017 Jul 10. SLAS Discov. 2017. PMID: 28692323 Free PMC article.

6

Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective.

Rainard JM, Pandarakalam GC, McElroy SP. Rainard JM, et al. SLAS Discov. 2018 Mar;23(3):225-241. doi: 10.1177/2472555217744728. SLAS Discov. 2018. PMID: 29460707 Free PMC article.

7

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing.

Pandarakalam GC, Speake M, McElroy S, Alturkistani A, Philippe L, Pettitt J, Müller B, Connolly B. Pandarakalam GC, et al. Among authors: mcelroy s. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:28-37. doi: 10.1016/j.ijpddr.2019.04.001. Epub 2019 Apr 5. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31015150 Free PMC article.

8

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.

Beck EM, Parnell E, Cowley A, Porter A, Gillespie J, Robinson J, Robinson L, Pannifer AD, Hamon V, Jones P, Morrison A, McElroy S, Timmerman M, Rutjes H, Mahajan P, Wiejak J, Luchowska-Stańska U, Morgan D, Barker G, Rehmann H, Yarwood SJ. Beck EM, et al. Among authors: mcelroy s. Cells. 2019 Nov 12;8(11):1425. doi: 10.3390/cells8111425. Cells. 2019. PMID: 31726720 Free PMC article.

9

The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets.

Zachari M, Rainard JM, Pandarakalam GC, Robinson L, Gillespie J, Rajamanickam M, Hamon V, Morrison A, Ganley IG, McElroy SP. Zachari M, et al. Biochem J. 2020 Feb 28;477(4):801-814. doi: 10.1042/BCJ20190846. Biochem J. 2020. PMID: 32011652 Free PMC article.

10

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants.

Monaghan AE, Porter A, Hunter I, Morrison A, McElroy SP, McEwan IJ. Monaghan AE, et al. Assay Drug Dev Technol. 2022 Apr;20(3):111-124. doi: 10.1089/adt.2021.128. Epub 2022 Mar 23. Assay Drug Dev Technol. 2022. PMID: 35333596 Free PMC article.

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