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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Townsend S, Fennell BJ, Apgar JR, Lambert M, McDonnell B, Grant J, Wade J, Franklin E, Foy N, Ní Shúilleabháin D, Fields C, Darmanin-Sheehan A, King A, Paulsen JE, Hickling TP, Tchistiakova L, Cunningham O, Finlay WJ. Townsend S, et al. Among authors: mcdonnell b. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15354-9. doi: 10.1073/pnas.1510944112. Epub 2015 Nov 30. Proc Natl Acad Sci U S A. 2015. PMID: 26621728 Free PMC article.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O. Fennell BJ, et al. Among authors: mcdonnell b. MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21. MAbs. 2013. PMID: 23995618 Free PMC article.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Avery LB, Wade J, Wang M, Tam A, King A, Piche-Nicholas N, Kavosi MS, Penn S, Cirelli D, Kurz JC, Zhang M, Cunningham O, Jones R, Fennell BJ, McDonnell B, Sakorafas P, Apgar J, Finlay WJ, Lin L, Bloom L, O'Hara DM. Avery LB, et al. Among authors: mcdonnell b. MAbs. 2018 Feb/Mar;10(2):244-255. doi: 10.1080/19420862.2017.1417718. Epub 2018 Jan 29. MAbs. 2018. PMID: 29271699 Free PMC article.
Cardiac biomarkers and the case for point-of-care testing.
McDonnell B, Hearty S, Leonard P, O'Kennedy R. McDonnell B, et al. Clin Biochem. 2009 May;42(7-8):549-61. doi: 10.1016/j.clinbiochem.2009.01.019. Epub 2009 Feb 7. Clin Biochem. 2009. PMID: 19318022 Review.
Iliocaval Venous Obstruction, Cardiac Preload Reserve and Exercise Limitation.
Morris RI, Sobotka PA, Balmforth PK, Stöhr EJ, McDonnell BJ, Spencer D, O'Sullivan GJ, Black SA. Morris RI, et al. J Cardiovasc Transl Res. 2020 Aug;13(4):531-539. doi: 10.1007/s12265-020-09963-w. Epub 2020 Feb 10. J Cardiovasc Transl Res. 2020. PMID: 32040765 Free PMC article. Review.
172 results