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Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives.
Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD. Nicholson HE, et al. Among authors: mccurdy cr. J Pharmacol Exp Ther. 2019 Feb;368(2):272-281. doi: 10.1124/jpet.118.253484. Epub 2018 Dec 7. J Pharmacol Exp Ther. 2019. PMID: 30530624 Free PMC article.
Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatography-tandem mass spectrometry.
Sharma A, Kamble SH, León F, Chear NJ, King TI, Berthold EC, Ramanathan S, McCurdy CR, Avery BA. Sharma A, et al. Among authors: mccurdy cr. Drug Test Anal. 2019 Aug;11(8):1162-1171. doi: 10.1002/dta.2604. Epub 2019 May 15. Drug Test Anal. 2019. PMID: 30997725 Free PMC article.
Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.
King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. King TI, et al. Among authors: mccurdy cr. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Dec 15;1134-1135:121875. doi: 10.1016/j.jchromb.2019.121875. Epub 2019 Nov 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 31790916 Free PMC article.
Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo.
Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Intagliata S, et al. Among authors: mccurdy cr. AAPS J. 2020 Jul 20;22(5):94. doi: 10.1208/s12248-020-00472-x. AAPS J. 2020. PMID: 32691179
188 results