McCoy MA - Search Results

1

Structure-Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation.

Pichon MM, Drelinkiewicz D, Lozano D, Moraru R, Hayward LJ, Jones M, McCoy MA, Allstrum-Graves S, Balourdas DI, Joerger AC, Whitby RJ, Goldup SM, Wells N, Langley GJ, Herniman JM, Baud MGJ. Pichon MM, et al. Among authors: mccoy ma. Bioconjug Chem. 2023 Sep 20;34(9):1679-1687. doi: 10.1021/acs.bioconjchem.3c00322. Epub 2023 Sep 1. Bioconjug Chem. 2023. PMID: 37657082 Free PMC article.

2

Insulin purification-Innovation continuum via synthesis of fundamentals, technology, and modeling.

Roush D, Iammarino M, Chmielowski R, Insaidoo F, McCoy MA, Ortigosa A, Rauscher M. Roush D, et al. Among authors: mccoy ma. Biotechnol Bioeng. 2023 May 18. doi: 10.1002/bit.28427. Online ahead of print. Biotechnol Bioeng. 2023. PMID: 37200159

3

Investigating protein-excipient interactions of a multivalent V_HH therapeutic protein using NMR spectroscopy.

Panchal J, Falk BT, Antochshuk V, McCoy MA. Panchal J, et al. Among authors: mccoy ma. MAbs. 2022 Jan-Dec;14(1):2124902. doi: 10.1080/19420862.2022.2124902. MAbs. 2022. PMID: 36166705 Free PMC article.

4

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.

Tawa P, Zhang L, Metwally E, Hou Y, McCoy MA, Seganish WM, Zhang R, Frank E, Sheth P, Hanisak J, Sondey C, Bauman D, Soriano A. Tawa P, et al. Among authors: mccoy ma. J Biol Chem. 2022 Sep;298(9):102284. doi: 10.1016/j.jbc.2022.102284. Epub 2022 Jul 19. J Biol Chem. 2022. PMID: 35868561 Free PMC article.

5

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.

McCoy MA, Spicer D, Wells N, Hoogewijs K, Fiedler M, Baud MGJ. McCoy MA, et al. J Med Chem. 2022 May 26;65(10):7246-7261. doi: 10.1021/acs.jmedchem.2c00228. Epub 2022 May 17. J Med Chem. 2022. PMID: 35581674 Free PMC article. Review.

6

Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.

Pissarnitski DA, Kekec A, Yan L, Zhu Y, Feng DD, Huo P, Madsen-Duggan C, Moyes CR, Nargund RP, Kelly T, Zhang X, Carballo-Jane E, Gorski J, Zafian P, Qatanani M, Kaarsholm N, Meng F, Jia X, Lee KJ, Wang W, Xu S, Hohn MJ, Iammarino MJ, McCoy MA, Okoh GA, Liang Y, Hollingsworth SA, Erion MD, Kelley DE, Garbaccio RM, Zhang A, Mu J, Lin S. Pissarnitski DA, et al. Among authors: mccoy ma. J Med Chem. 2022 Apr 14;65(7):5593-5605. doi: 10.1021/acs.jmedchem.1c02073. Epub 2022 Mar 17. J Med Chem. 2022. PMID: 35298158

7

NMR Data-Driven Docking of HDM2-Inhibitor Complexes.

Fradera X, Reutershan MH, Machacek MR, Trotter BW, McCoy MA. Fradera X, et al. Among authors: mccoy ma. Chembiochem. 2022 Mar 18;23(6):e202100570. doi: 10.1002/cbic.202100570. Epub 2022 Feb 21. Chembiochem. 2022. PMID: 35104390

8

Probing IgG1 F_C-Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach.

Gudhka RB, Vats M, Bilodeau CL, McCallum SA, McCoy MA, Roush DJ, Snyder MA, Cramer SM. Gudhka RB, et al. Among authors: mccoy ma. Langmuir. 2021 Oct 19;37(41):12188-12203. doi: 10.1021/acs.langmuir.1c02114. Epub 2021 Oct 11. Langmuir. 2021. PMID: 34633195

9

Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments.

Ban D, Rice CT, McCoy MA. Ban D, et al. Among authors: mccoy ma. MAbs. 2021 Jan-Dec;13(1):1978132. doi: 10.1080/19420862.2021.1978132. MAbs. 2021. PMID: 34612804 Free PMC article.

10

Identification of preferred multimodal ligand-binding regions on IgG1 F_C using nuclear magnetic resonance and molecular dynamics simulations.

Gudhka RB, Bilodeau CL, McCallum SA, McCoy MA, Roush DJ, Snyder MA, Cramer SM. Gudhka RB, et al. Among authors: mccoy ma. Biotechnol Bioeng. 2021 Feb;118(2):809-822. doi: 10.1002/bit.27611. Epub 2020 Nov 6. Biotechnol Bioeng. 2021. PMID: 33107976

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