McCoy M - Search Results

1

The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.

Labroli MA, Dwyer MP, Shen R, Popovici-Muller J, Pu Q, Wyss D, McCoy M, Barrett D, Davis N, Seghezzi W, Shanahan F, Taricani L, Beaumont M, Malinao MC, Parry D, Guzi TJ. Labroli MA, et al. Among authors: mccoy m. Bioorg Med Chem. 2014 Apr 1;22(7):2303-10. doi: 10.1016/j.bmc.2014.02.007. Epub 2014 Feb 15. Bioorg Med Chem. 2014. PMID: 24588962

2

Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.

Wyss DF, Arasappan A, Senior MM, Wang YS, Beyer BM, Njoroge FG, McCoy MA. Wyss DF, et al. Among authors: mccoy ma. J Med Chem. 2004 May 6;47(10):2486-98. doi: 10.1021/jm0305117. J Med Chem. 2004. PMID: 15115392

3

NMR-based approaches for lead discovery.

Wyss DF, McCoy MA, Senior MM. Wyss DF, et al. Among authors: mccoy ma. Curr Opin Drug Discov Devel. 2002 Jul;5(4):630-47. Curr Opin Drug Discov Devel. 2002. PMID: 12197321 Review.

4

Spatial localization of ligand binding sites from electron current density surfaces calculated from NMR chemical shift perturbations.

McCoy MA, Wyss DF. McCoy MA, et al. J Am Chem Soc. 2002 Oct 2;124(39):11758-63. doi: 10.1021/ja026166c. J Am Chem Soc. 2002. PMID: 12296743

5

NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.

Hou Y, Mayhood T, Sheth P, Tan CM, Labroli M, Su J, Wyss DF, Roemer T, McCoy MA. Hou Y, et al. Among authors: mccoy ma. J Biomol Screen. 2016 Jul;21(6):579-89. doi: 10.1177/1087057116640199. Epub 2016 Mar 29. J Biomol Screen. 2016. PMID: 27028606

6

Structures of protein-protein complexes are docked using only NMR restraints from residual dipolar coupling and chemical shift perturbations.

McCoy MA, Wyss DF. McCoy MA, et al. J Am Chem Soc. 2002 Mar 13;124(10):2104-5. doi: 10.1021/ja017242z. J Am Chem Soc. 2002. PMID: 11878950

7

Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation.

McCoy MA, Gesell JJ, Senior MM, Wyss DF. McCoy MA, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1645-8. doi: 10.1073/pnas.0334477100. Epub 2003 Jan 27. Proc Natl Acad Sci U S A. 2003. PMID: 12552135 Free PMC article.

8

Screening of protein kinases by ATP-STD NMR spectroscopy.

McCoy MA, Senior MM, Wyss DF. McCoy MA, et al. J Am Chem Soc. 2005 Jun 8;127(22):7978-9. doi: 10.1021/ja0425942. J Am Chem Soc. 2005. PMID: 15926798

9

Alignment of weakly interacting molecules to protein surfaces using simulations of chemical shift perturbations.

McCoy MA, Wyss DF. McCoy MA, et al. J Biomol NMR. 2000 Nov;18(3):189-98. doi: 10.1023/a:1026508025631. J Biomol NMR. 2000. PMID: 11142509

10

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.

Huang X, Shipps GW Jr, Cheng CC, Spacciapoli P, Zhang X, McCoy MA, Wyss DF, Yang X, Achab A, Soucy K, Montavon DK, Murphy DM, Whitehurst CE. Huang X, et al. Among authors: mccoy ma. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7. doi: 10.1021/ml200113y. eCollection 2011 Aug 11. ACS Med Chem Lett. 2011. PMID: 24900358 Free PMC article.

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