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Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
Nat Commun. 2022 Jan 20;13(1):424. doi: 10.1038/s41467-022-28061-w.
Nat Commun. 2022.
PMID: 35058456
Free PMC article.
Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.
Oh E, McCown EM, Ahn M, Garcia PA, Branciamore S, Tang S, Zeng DF, Roep BO, Thurmond DC.
Oh E, et al. Among authors: mccown em.
Diabetes. 2021 Dec;70(12):2837-2849. doi: 10.2337/db21-0170. Epub 2021 Sep 23.
Diabetes. 2021.
PMID: 34556496
Free PMC article.
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Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis.
Merz KE, Tunduguru R, Ahn M, Salunkhe VA, Veluthakal R, Hwang J, Bhattacharya S, McCown EM, Garcia PA, Zhou C, Oh E, Yoder SM, Elmendorf JS, Thurmond DC.
Merz KE, et al. Among authors: mccown em.
Front Endocrinol (Lausanne). 2022 Feb 11;13:821849. doi: 10.3389/fendo.2022.821849. eCollection 2022.
Front Endocrinol (Lausanne). 2022.
PMID: 35222279
Free PMC article.
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A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis.
Ahn M, Oh E, McCown EM, Wang X, Veluthakal R, Thurmond DC.
Ahn M, et al. Among authors: mccown em.
Metabolism. 2021 Feb;115:154431. doi: 10.1016/j.metabol.2020.154431. Epub 2020 Nov 10.
Metabolism. 2021.
PMID: 33181191
Free PMC article.
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