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Page 1
The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair.
McCowan J, Fercoq F, Kirkwood PM, T'Jonck W, Hegarty LM, Mawer CM, Cunningham R, Mirchandani AS, Hoy A, Humphries DC, Jones GR, Hansen CG, Hirani N, Jenkins SJ, Henri S, Malissen B, Walmsley SR, Dockrell DH, Saunders PTK, Carlin LM, Bain CC. McCowan J, et al. Sci Immunol. 2021 Nov 19;6(65):eabj2132. doi: 10.1126/sciimmunol.abj2132. Epub 2021 Nov 19. Sci Immunol. 2021. PMID: 34797692 Free PMC article.
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK, Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S, Smith EC, Vieth M, Weir LC, Yan L, Zhang F, Yingling JM. Sawyer JS, et al. Among authors: mccowan jr. J Med Chem. 2003 Sep 11;46(19):3953-6. doi: 10.1021/jm0205705. J Med Chem. 2003. PMID: 12954047
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF. Thomas J, et al. Among authors: mccowan j. J Biol Chem. 2003 Jan 24;278(4):2403-10. doi: 10.1074/jbc.M209629200. Epub 2002 Nov 18. J Biol Chem. 2003. PMID: 12441342 Free article.
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA. Fisher MJ, et al. Among authors: mccowan jr. Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9. doi: 10.1016/s0960-894x(00)00008-1. Bioorg Med Chem Lett. 2000. PMID: 10714506
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives.
Sall DJ, Bailey DL, Bastian JA, Buben JA, Chirgadze NY, Clemens-Smith AC, Denney ML, Fisher MJ, Giera DD, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Richett ME, Smith GF, Snyder DW, Takeuchi K, Toth JE, Zhang M. Sall DJ, et al. Among authors: mccowan jr. J Med Chem. 2000 Feb 24;43(4):649-63. doi: 10.1021/jm9903388. J Med Chem. 2000. PMID: 10691691
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.
Zhang M, Bailey DL, Bastian JA, Briggs SL, Chirgadze NY, Clawson DK, Denney ML, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Richett ME, Sall DJ, Smith AJ, Smith GF, Snyder DW, Takeuchi K, Utterback BG, Yan SC. Zhang M, et al. Among authors: mccowan jr. Bioorg Med Chem Lett. 1999 Mar 8;9(5):775-80. doi: 10.1016/s0960-894x(99)00074-8. Bioorg Med Chem Lett. 1999. PMID: 10201846
23 results