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A non-hallucinogenic LSD analog with therapeutic potential for mood disorders.
Lewis V, Bonniwell EM, Lanham JK, Ghaffari A, Sheshbaradaran H, Cao AB, Calkins MM, Bautista-Carro MA, Arsenault E, Telfer A, Taghavi-Abkuh FF, Malcolm NJ, El Sayegh F, Abizaid A, Schmid Y, Morton K, Halberstadt AL, Aguilar-Valles A, McCorvy JD. Lewis V, et al. Among authors: mccorvy jd. Cell Rep. 2023 Mar 28;42(3):112203. doi: 10.1016/j.celrep.2023.112203. Epub 2023 Mar 6. Cell Rep. 2023. PMID: 36884348 Free PMC article.
Molecular insights into GPCR mechanisms for drugs of abuse.
Sanchez-Reyes OB, Zilberg G, McCorvy JD, Wacker D. Sanchez-Reyes OB, et al. Among authors: mccorvy jd. J Biol Chem. 2023 Sep;299(9):105176. doi: 10.1016/j.jbc.2023.105176. Epub 2023 Aug 18. J Biol Chem. 2023. PMID: 37599003 Free PMC article. Review.
Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity.
Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL. Balapattabi K, et al. Among authors: mccorvy jd. Cell Rep. 2023 Aug 29;42(8):112935. doi: 10.1016/j.celrep.2023.112935. Epub 2023 Aug 2. Cell Rep. 2023. PMID: 37540598 Free PMC article.
Bioisosteric analogs of MDMA with improved pharmacological profile.
Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH. Alberto-Silva AS, et al. Among authors: mccorvy jd. bioRxiv [Preprint]. 2024 Apr 11:2024.04.08.588083. doi: 10.1101/2024.04.08.588083. bioRxiv. 2024. PMID: 38645142 Free PMC article. Preprint.
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential.
Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Wallach J, et al. Among authors: mccorvy jd. Nat Commun. 2023 Dec 15;14(1):8221. doi: 10.1038/s41467-023-44016-1. Nat Commun. 2023. PMID: 38102107 Free PMC article.
74 results