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Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.
Kandasamy P, McClorey G, Shimizu M, Kothari N, Alam R, Iwamoto N, Kumarasamy J, Bommineni GR, Bezigian A, Chivatakarn O, Butler DCD, Byrne M, Chwalenia K, Davies KE, Desai J, Shelke JD, Durbin AF, Ellerington R, Edwards B, Godfrey J, Hoss A, Liu F, Longo K, Lu G, Marappan S, Oieni J, Paik IH, Estabrook EP, Shivalila C, Tischbein M, Kawamoto T, Rinaldi C, Rajão-Saraiva J, Tripathi S, Yang H, Yin Y, Zhao X, Zhou C, Zhang J, Apponi L, Wood MJA, Vargeese C. Kandasamy P, et al. Among authors: mcclorey g. Nucleic Acids Res. 2022 Jun 10;50(10):5443-5466. doi: 10.1093/nar/gkac018. Nucleic Acids Res. 2022. PMID: 35061895 Free PMC article.
Extracellular microRNAs are dynamic non-vesicular biomarkers of muscle turnover.
Roberts TC, Godfrey C, McClorey G, Vader P, Briggs D, Gardiner C, Aoki Y, Sargent I, Morgan JE, Wood MJ. Roberts TC, et al. Among authors: mcclorey g. Nucleic Acids Res. 2013 Nov;41(20):9500-13. doi: 10.1093/nar/gkt724. Epub 2013 Aug 14. Nucleic Acids Res. 2013. PMID: 23945935 Free PMC article.
Splice-Switching Therapy for Spinal Muscular Atrophy.
Meijboom KE, Wood MJA, McClorey G. Meijboom KE, et al. Among authors: mcclorey g. Genes (Basel). 2017 Jun 12;8(6):161. doi: 10.3390/genes8060161. Genes (Basel). 2017. PMID: 28604635 Free PMC article. Review.
Exon skipping induces uniform dystrophin rescue with dose-dependent restoration of serum miRNA biomarkers and muscle biophysical properties.
Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC. Chwalenia K, et al. Among authors: mcclorey g. Mol Ther Nucleic Acids. 2022 Aug 25;29:955-968. doi: 10.1016/j.omtn.2022.08.033. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36159597 Free PMC article.
Small RNA-Mediated Epigenetic Myostatin Silencing.
Roberts TC, Andaloussi SE, Morris KV, McClorey G, Wood MJ. Roberts TC, et al. Among authors: mcclorey g. Mol Ther Nucleic Acids. 2012 May 15;1(5):e23. doi: 10.1038/mtna.2012.15. Mol Ther Nucleic Acids. 2012. PMID: 23344003 Free PMC article.
Design and application of bispecific splice-switching oligonucleotides.
Bestas B, McClorey G, Tedebark U, Moreno PM, Roberts TC, Hammond SM, Smith CI, Wood MJ, Andaloussi SE. Bestas B, et al. Among authors: mcclorey g. Nucleic Acid Ther. 2014 Feb;24(1):13-24. doi: 10.1089/nat.2013.0462. Nucleic Acid Ther. 2014. PMID: 24506779
40 results