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449 results

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Page 1
Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease.
Mrdjen M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell M, Radaeva S, Barton B, Szabo G, Dasarathy S, Wang Z, Hazen SL, Brown JM, Nagy LE. Mrdjen M, et al. Among authors: mcclain cj. Hepatol Commun. 2023 Oct 12;7(11):e0284. doi: 10.1097/HC9.0000000000000284. eCollection 2023 Nov 1. Hepatol Commun. 2023. PMID: 37820283 Free PMC article.
Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans.
Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE. Miyata T, et al. Among authors: mcclain cj. JCI Insight. 2022 Dec 8;7(23):e167011. doi: 10.1172/jci.insight.167011. JCI Insight. 2022. PMID: 36477363 Free PMC article. No abstract available.
Design of a multicenter randomized clinical trial for treatment of Alcohol-Associated Hepatitis.
Tu W, Gawrieh S, Dasarathy S, Mitchell MC, Simonetto DA, Patidar KR, McClain CJ, Bataller R, Szabo G, Tang Q, Barton BA, Radaeva S, Sanyal AJ, Shah V; Alcoholic Hepatitis Network (AlcHepNet) Investigators. Tu W, et al. Among authors: mcclain cj. Contemp Clin Trials Commun. 2023 Jan 18;32:101074. doi: 10.1016/j.conctc.2023.101074. eCollection 2023 Apr. Contemp Clin Trials Commun. 2023. PMID: 36698742 Free PMC article.
Reply.
Szabo G, Mitchell MC, Dasarathy S, McClain C. Szabo G, et al. Hepatology. 2023 May 1;77(5):E115. doi: 10.1097/HEP.0000000000000337. Epub 2023 Feb 24. Hepatology. 2023. PMID: 36815366 No abstract available.
Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.
de Carvalho Ribeiro M, Iracheta-Vellve A, Babuta M, Calenda CD, Copeland C, Zhuang Y, Lowe PP, Hawryluk D, Catalano D, Cho Y, Barton B, Dasarathy S, McClain C, McCullough AJ, Mitchell MC, Nagy LE, Radaeva S, Lien E, Golenbock DT, Szabo G. de Carvalho Ribeiro M, et al. Hepatology. 2023 Jul 1;78(1):225-242. doi: 10.1097/HEP.0000000000000298. Epub 2023 Mar 3. Hepatology. 2023. PMID: 36862512
Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis.
Hassanein T, McClain CJ, Vatsalya V, Stein LL, Flamm SL, Martin P, Cave MC, Mitchell M Jr, Barton B, Nagy L, Szabo G, McCullough A, Dasarathy S, Shah J, Blevins C, Scott D, Krebs W, Brown JE, Lin W. Hassanein T, et al. Among authors: mcclain cj. Am J Gastroenterol. 2024 Jan 1;119(1):107-115. doi: 10.14309/ajg.0000000000002275. Epub 2023 Apr 3. Am J Gastroenterol. 2024. PMID: 37011138 Free PMC article.
449 results