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Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC. Zeitlin L, et al. Among authors: mccavitt malvido m. Sci Transl Med. 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569014
Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination.
Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Kumar GR, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Kojima N, Arellanor T, Bussanich A, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Wang Y, Ghazarian S, Davis G, Rodriguez D, Doudna J, Spraggon L, Chiu CY, Ott M. Suryawanshi RK, et al. Among authors: mccavitt malvido m. Emerg Microbes Infect. 2023 Dec;12(2):2270071. doi: 10.1080/22221751.2023.2270071. Epub 2023 Oct 31. Emerg Microbes Infect. 2023. PMID: 37869789 Free PMC article.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. Among authors: mccavitt malvido m. PLoS Pathog. 2023 Aug 31;19(8):e1011614. doi: 10.1371/journal.ppat.1011614. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37651466 Free PMC article.
Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ. Upadhyay V, et al. Among authors: mccavitt malvido m. mBio. 2023 Aug 31;14(4):e0088923. doi: 10.1128/mbio.00889-23. Epub 2023 Jun 9. mBio. 2023. PMID: 37294090 Free PMC article.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. Among authors: mccavitt malvido m. bioRxiv [Preprint]. 2023 May 10:2023.04.18.537104. doi: 10.1101/2023.04.18.537104. bioRxiv. 2023. PMID: 37131711 Free PMC article. Updated. Preprint.
Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi R, Tasoff P, McCavitt-Malvido M, Kumar GR, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha C, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ. Upadhyay V, et al. Among authors: mccavitt malvido m. bioRxiv [Preprint]. 2022 Dec 8:2022.12.07.519508. doi: 10.1101/2022.12.07.519508. bioRxiv. 2022. PMID: 36523400 Free PMC article. Updated. Preprint.
Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a Pan-Ebolavirus Immunotherapeutic.
Kuang E, Cross RW, McCavitt-Malvido M, Abelson DM, Borisevich V, Stuart L, Agans KN, Mlakar N, Marimuthu A, Deer DJ, Shestowsky WS, Kim D, Geisbert JB, Zeitlin L, Moyer CL, Roy CJ, Geisbert TW, Bornholdt ZA. Kuang E, et al. Among authors: mccavitt malvido m. Pathogens. 2022 Jun 7;11(6):655. doi: 10.3390/pathogens11060655. Pathogens. 2022. PMID: 35745509 Free PMC article.