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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Ledsgaard L, Wade J, Jenkins TP, Boddum K, Oganesyan I, Harrison JA, Villar P, Leah RA, Zenobi R, Schoffelen S, Voldborg B, Ljungars A, McCafferty J, Lomonte B, Gutiérrez JM, Laustsen AH, Karatt-Vellatt A. Ledsgaard L, et al. Among authors: mccafferty j. Nat Commun. 2023 Feb 8;14(1):682. doi: 10.1038/s41467-023-36393-4. Nat Commun. 2023. PMID: 36755049 Free PMC article.
Engineering therapeutic proteins.
McCafferty J, Glover DR. McCafferty J, et al. Curr Opin Struct Biol. 2000 Aug;10(4):417-20. doi: 10.1016/s0959-440x(00)00108-1. Curr Opin Struct Biol. 2000. PMID: 10981628 Review.
Cross-domain inhibition of TACE ectodomain.
Tape CJ, Willems SH, Dombernowsky SL, Stanley PL, Fogarasi M, Ouwehand W, McCafferty J, Murphy G. Tape CJ, et al. Among authors: mccafferty j. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5578-83. doi: 10.1073/pnas.1017067108. Epub 2011 Mar 17. Proc Natl Acad Sci U S A. 2011. PMID: 21415364 Free PMC article.
Directing phage selections towards specific epitopes.
Parsons HL, Earnshaw JC, Wilton J, Johnson KS, Schueler PA, Mahoney W, McCafferty J. Parsons HL, et al. Among authors: mccafferty j. Protein Eng. 1996 Nov;9(11):1043-9. doi: 10.1093/protein/9.11.1043. Protein Eng. 1996. PMID: 8961357
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.
Minnis-Lyons SE, Ferreira-González S, Aleksieva N, Man TY, Gadd VL, Williams MJ, Guest RV, Lu WY, Dwyer BJ, Jamieson T, Nixon C, Van Hul N, Lemaigre FP, McCafferty J, Leclercq IA, Sansom OJ, Boulter L, Forbes SJ. Minnis-Lyons SE, et al. Among authors: mccafferty j. Sci Signal. 2021 Jun 22;14(688):eaay9185. doi: 10.1126/scisignal.aay9185. Sci Signal. 2021. PMID: 34158399
Application of phage display to high throughput antibody generation and characterization.
Schofield DJ, Pope AR, Clementel V, Buckell J, Chapple SDj, Clarke KF, Conquer JS, Crofts AM, Crowther SR, Dyson MR, Flack G, Griffin GJ, Hooks Y, Howat WJ, Kolb-Kokocinski A, Kunze S, Martin CD, Maslen GL, Mitchell JN, O'Sullivan M, Perera RL, Roake W, Shadbolt SP, Vincent KJ, Warford A, Wilson WE, Xie J, Young JL, McCafferty J. Schofield DJ, et al. Among authors: mccafferty j. Genome Biol. 2007;8(11):R254. doi: 10.1186/gb-2007-8-11-r254. Genome Biol. 2007. PMID: 18047641 Free PMC article.
Recombinant antibodies and in vitro selection technologies.
Geyer CR, McCafferty J, Dübel S, Bradbury AR, Sidhu SS. Geyer CR, et al. Among authors: mccafferty j. Methods Mol Biol. 2012;901:11-32. doi: 10.1007/978-1-61779-931-0_2. Methods Mol Biol. 2012. PMID: 22723092 Review.
131 results