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Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.
Cell. 2018.
PMID: 30053426
Free PMC article.
Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events.
Lin JJY, Low-Nam ST, Alfieri KN, McAffee DB, Fay NC, Groves JT.
Lin JJY, et al. Among authors: mcaffee db.
Sci Signal. 2019 Jan 15;12(564):eaat8715. doi: 10.1126/scisignal.aat8715.
Sci Signal. 2019.
PMID: 30647147
Free PMC article.
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How the T cell signaling network processes information to discriminate between self and agonist ligands.
Ganti RS, Lo WL, McAffee DB, Groves JT, Weiss A, Chakraborty AK.
Ganti RS, et al. Among authors: mcaffee db.
Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26020-26030. doi: 10.1073/pnas.2008303117. Epub 2020 Oct 5.
Proc Natl Acad Sci U S A. 2020.
PMID: 33020303
Free PMC article.
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Height, but not binding epitope, affects the potency of synthetic TCR agonists.
Wilhelm KB, Morita S, McAffee DB, Kim S, O'Dair MK, Groves JT.
Wilhelm KB, et al. Among authors: mcaffee db.
Biophys J. 2021 Sep 21;120(18):3869-3880. doi: 10.1016/j.bpj.2021.08.027. Epub 2021 Aug 26.
Biophys J. 2021.
PMID: 34453921
Free PMC article.
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Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.
Karandur D, Bhattacharyya M, Xia Z, Lee YK, Muratcioglu S, McAffee D, McSpadden ED, Qiu B, Groves JT, Williams ER, Kuriyan J.
Karandur D, et al. Among authors: mcaffee d.
Elife. 2020 Sep 9;9:e57784. doi: 10.7554/eLife.57784.
Elife. 2020.
PMID: 32902386
Free PMC article.
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Height, but not binding epitope, affects the potency of synthetic TCR agonists.
Wilhelm KB, Morita S, McAffee DB, Kim S, O'Dair MK, Groves JT.
Wilhelm KB, et al. Among authors: mcaffee db.
Biophys J. 2021 Nov 16;120(22):5136-5137. doi: 10.1016/j.bpj.2021.10.022. Epub 2021 Nov 6.
Biophys J. 2021.
PMID: 34742402
Free PMC article.
No abstract available.
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Discrete LAT condensates encode antigen information from single pMHC:TCR binding events.
McAffee DB, O'Dair MK, Lin JJ, Low-Nam ST, Wilhelm KB, Kim S, Morita S, Groves JT.
McAffee DB, et al.
Nat Commun. 2022 Dec 2;13(1):7446. doi: 10.1038/s41467-022-35093-9.
Nat Commun. 2022.
PMID: 36460640
Free PMC article.
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