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CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, Fontanillo C, Tran E, Contreras A, Ng SWK, Matyskiela M, Wang K, Chamberlain P, Cathers B, Carmichael J, Hansen J, Wang JCY, Minden MD, Fan J, Pierce DW, Pourdehnad M, Rolfe M, Lopez-Girona A, Dick JE, Lu G. Surka C, et al. Among authors: mbong n. Blood. 2021 Feb 4;137(5):661-677. doi: 10.1182/blood.2020008676. Blood. 2021. PMID: 33197925 Free PMC article.
An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers.
Chen WC, Yuan JS, Xing Y, Mitchell A, Mbong N, Popescu AC, McLeod J, Gerhard G, Kennedy JA, Bogdanoski G, Lauriault S, Perdu S, Merkulova Y, Minden MD, Hogge DE, Guidos C, Dick JE, Wang JC. Chen WC, et al. Among authors: mbong n. Cancer Res. 2016 Mar 1;76(5):1214-24. doi: 10.1158/0008-5472.CAN-15-2743. Epub 2016 Feb 1. Cancer Res. 2016. PMID: 26833125
SIRPαFc treatment targets human acute myeloid leukemia stem cells.
Galkin O, McLeod J, Kennedy JA, Jin L, Mbong N, Wong M, Uger RA, Minden MD, Danska JS, Wang JCY. Galkin O, et al. Among authors: mbong n. Haematologica. 2021 Jan 1;106(1):279-283. doi: 10.3324/haematol.2019.245167. Haematologica. 2021. PMID: 32054659 Free PMC article. No abstract available.
Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target.
Vanner RJ, Dobson SM, Gan OI, McLeod J, Schoof EM, Grandal I, Wintersinger JA, Garcia-Prat L, Hosseini M, Xie SZ, Jin L, Mbong N, Voisin V, Chan-Seng-Yue M, Kennedy JA, Waanders E, Morris Q, Porse B, Chan SM, Guidos CJ, Danska JS, Minden MD, Mullighan CG, Dick JE. Vanner RJ, et al. Among authors: mbong n. Blood Cancer Discov. 2022 Jan;3(1):16-31. doi: 10.1158/2643-3230.BCD-20-0216. Epub 2021 Oct 11. Blood Cancer Discov. 2022. PMID: 35019858 Free PMC article.
Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.
Krivdova G, Voisin V, Schoof EM, Marhon SA, Murison A, McLeod JL, Gabra MM, Zeng AGX, Aigner S, Yee BA, Shishkin AA, Van Nostrand EL, Hermans KG, Trotman-Grant AC, Mbong N, Kennedy JA, Gan OI, Wagenblast E, De Carvalho DD, Salmena L, Minden MD, Bader GD, Yeo GW, Dick JE, Lechman ER. Krivdova G, et al. Among authors: mbong n. Cell Rep. 2022 Mar 8;38(10):110481. doi: 10.1016/j.celrep.2022.110481. Cell Rep. 2022. PMID: 35263585 Free article.
AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.
Pereira DS, Guevara CI, Jin L, Mbong N, Verlinsky A, Hsu SJ, Aviña H, Karki S, Abad JD, Yang P, Moon SJ, Malik F, Choi MY, An Z, Morrison K, Challita-Eid PM, Doñate F, Joseph IB, Kipps TJ, Dick JE, Stover DR. Pereira DS, et al. Among authors: mbong n. Mol Cancer Ther. 2015 Jul;14(7):1650-60. doi: 10.1158/1535-7163.MCT-15-0067. Epub 2015 May 1. Mol Cancer Ther. 2015. PMID: 25934707 Free PMC article.
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.
Boutzen H, Madani Tonekaboni SA, Chan-Seng-Yue M, Murison A, Takayama N, Mbong N, Wagenblast E, Orouji E, Arruda A, Mitchell A, Notta F, Minden MD, Lupien M, Kaufmann KB, Dick JE. Boutzen H, et al. Among authors: mbong n. Leukemia. 2022 Nov;36(11):2690-2704. doi: 10.1038/s41375-022-01697-9. Epub 2022 Sep 21. Leukemia. 2022. PMID: 36131042 Free PMC article.
Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.
van Galen P, Kreso A, Wienholds E, Laurenti E, Eppert K, Lechman ER, Mbong N, Hermans K, Dobson S, April C, Fan JB, Dick JE. van Galen P, et al. Among authors: mbong n. Cell Stem Cell. 2014 Jan 2;14(1):94-106. doi: 10.1016/j.stem.2013.11.021. Cell Stem Cell. 2014. PMID: 24388174 Free article.
TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding.
Petrova PS, Viller NN, Wong M, Pang X, Lin GH, Dodge K, Chai V, Chen H, Lee V, House V, Vigo NT, Jin D, Mutukura T, Charbonneau M, Truong T, Viau S, Johnson LD, Linderoth E, Sievers EL, Maleki Vareki S, Figueredo R, Pampillo M, Koropatnick J, Trudel S, Mbong N, Jin L, Wang JC, Uger RA. Petrova PS, et al. Among authors: mbong n. Clin Cancer Res. 2017 Feb 15;23(4):1068-1079. doi: 10.1158/1078-0432.CCR-16-1700. Epub 2016 Nov 17. Clin Cancer Res. 2017. PMID: 27856600
14 results